Compile Data Set for Download or QSAR
Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50016842
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597704(CHEBI:28013 | Fosfructose | FOSFRUCTOSE)
Affinity DataEC50:  23nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50361557(CHEMBL1089334)
Affinity DataEC50:  38nMAssay Description:Activation of human recombinant full length His-tagged PKM2 (Asp354, Lys311, Glu397, Gly315 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50361557(CHEMBL1089334)
Affinity DataEC50:  38nMAssay Description:Activation of PKM2 (unknown origin) Asp354, Phe26, Lys311 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597709(CHEMBL1084625)
Affinity DataEC50:  38nMAssay Description:Activation of PKM2 (unknown origin) Phe26, Tyr390, Glu397, Leu353 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597710(CHEMBL5201754)
Affinity DataEC50:  90nMAssay Description:Activation of PKM2 (unknown origin) Glu397, Phe26, Tyr390, Leu353 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597711(CHEMBL5178887)
Affinity DataEC50:  5.50E+3nMAssay Description:Activation of PKM2 (unknown origin) Leu353, Leu398, Glu397, Tyr390, Phe26 residues assessed as ATP formation preincubated for 30 mins followed by ADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597712(CHEMBL5179096)
Affinity DataEC50:  56nMAssay Description:Activation of PKM2 (unknown origin) Leu353, Tyr390, Phe26, Glu397, Lys311, Asp354 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597713(CHEMBL5190040)
Affinity DataEC50:  228nMAssay Description:Activation of PKM2 (unknown origin) Glu397, Phe26, Leu353, Gly355 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597714(Mitapivat | Ag-348 | Pkr-in-1 | AG-348 | MITAPIVAT...)
Affinity DataEC50:  37nMAssay Description:Activation of PKM2 (unknown origin) Lys311, Asp354, Met30, Phe26 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50357212(Serine | (L)-SERINE)
Affinity DataEC50:  1.30E+6nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597703(CHEMBL3727658)
Affinity DataEC50: <100nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597702(CHEMBL5200796)
Affinity DataEC50: <100nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597701(CHEMBL3104587)
Affinity DataEC50:  260nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597700(CHEMBL3732472)
Affinity DataEC50: <100nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597699(CHEMBL5170943)
Affinity DataEC50: <100nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597698(CHEMBL5187654)
Affinity DataEC50:  4.92E+3nMAssay Description:Activation of PKM2 (unknown origin) Leu353, Tyr390, Phe26 residues incubated for 30 mins by ATP colorimetric/fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataEC50:  0.510nMAssay Description:Activation of recombinant PKM2 (unknown origin) Phe26, Tyr390, Glu397, Asp354, Leu353 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50241354(Quercetin 3-O-beta-D-glucoside | quercetin 3-O-glu...)
Affinity DataEC50:  1.30nMAssay Description:Activation of recombinant PKM2 (unknown origin) Glu397, Lys3I I, Asp354, Leu353, Tyr390, His391 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50455475(CHEMBL1085588)
Affinity DataEC50:  92nMAssay Description:Activation of human recombinant full length His-tagged PKM2 (Asp354, Lys311, Glu397, Gly315 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597717(CHEMBL3609603)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Ser205, Asp177, Asp178, Lys207, Hie78, Gly128, Gly52, Ile51, Asn75, Hie84, Ser77, Lys367 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50033731(5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...)
Affinity DataIC50: 800nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50135169((2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-...)
Affinity DataIC50: 850nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Ser362, Ser205, Gly128, Lys207, Asp177, Hie84, Arg120, Ile51, Lys367 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597697(CHEBI:2578 | E103 | ALKANNIN)
Affinity DataIC50: 900nMAssay Description:Inhibition of PKM2 (unknown origin) Hie78, Lys207, Asn75, Ile51, Ser362, Ser205, Gly128 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM7457(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-on...)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Gly128, Asp177, Asp178, Ser362, Hie78, Be51, Asn75 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597697(CHEBI:2578 | E103 | ALKANNIN)
Affinity DataIC50: 900nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597706(CHEMBL5189727)
Affinity DataIC50: 960nMAssay Description:Inhibition of human N-terminal His tagged PKM2 expressed in Escherichia coli Gly128, Ser205, Lys367, Gly208, Ile335, Gly363, Asn75, Ser362, lle51 res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataIC50: 990nMAssay Description:Allosteric inhibition of PKM2 (unknown origin) assessed as oxidation of beta-NADH per minuteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataIC50: 990nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Asp177, Asp178, Asn75, Ile51, Gly128, Hie78, Lys367 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Asp178, Asp177, Hie78, Lys367, Asn75, Il61, Ser362, Gly128 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50081950(6-hydroxy-2-phenyl-4H-chromen-4-one | NSC-26744 | ...)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Gly128, Lys207, Hie78, Asn75, Ile51, Lys367, Gly79 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM23417(cid_72276 | (-)-Epicatechin | (2R,3R)-2-(3,4-dihyd...)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Asp177, Ser77, Gly52, Gly128 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Thr129, Ser205, Hie78, Lys367, Ala366, Gly52 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50009353(spermidine | 4-azaoctane-1,8-diamine | 4-azaoctame...)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of PKM2 (unknown origin) Gly128, Hie78, Hie84, Lys207, Asp177, Lys367, Ile51 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597715(CHEMBL4877010)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PKM2 (unknown origin) Hie78, Gln329, Asp178, Ser362, Asn75, Ile51 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50140257(CHEMBL16171 | 5,7-Dihydroxy-8-methoxy-2-phenyl-chr...)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of PKM2 (unknown origin) Ser205, Lys207, Hie78, Lys367, Asn75, Ile51, Thr129 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM26664(7-Hydroxy-flavone, 5a | 7-Hydroxyflavone, 11 | 7-h...)
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Ile335, Lys367, Lys207, Thr129, Lys206, Lys207, Asn75, Hie78 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase(Leishmania mexicana)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597707(CHEMBL5171047)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Leishmania mexicana PYK (Asn75, Il61, Ser362, Arg73, Gln329 residues) incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597716(CHEBI:2672 | Oxymatrine | OXYMATRINE)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PKM2 (unknown origin) Ala366, Hie78, Asn75, Lys207, Gly363 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597707(CHEMBL5171047)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human erythrocytes pyruvate kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50033731(5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...)
Affinity DataIC50: 8.82E+3nMAssay Description:Inhibition of human N-terminal His tagged PKM2 expressed in Escherichia coli Gly128, Ser205, Lys367, Gly208, Ile335, Gly363, Asn75, Ser362, lle51 res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50214744(Ferulic acid (M5) | ferulic acid | CHEMBL32749 | (...)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of PKM2 (unknown origin) Lys207, Hie78, Asp177, Asn75, Thr129, Gly128, Arg73 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50187132(Syringic acid | 3,5-Dimethoxy-4-hydroxybenzoic aci...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597707(CHEMBL5171047)
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of human pyruvate kinase in embryonic cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597707(CHEMBL5171047)
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of human pyruvate kinase in tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50597705(CHEMBL5189951)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human N-terminal 6x-His tagged PKM2 expressed Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50233673(cid_3718 | (+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)p...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of PKM2 (unknown origin) Gln329, Asp177, Lys207, Ser77, Hie78, Arg73, Ser362 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50134315(CHEMBL331627 | 7-hydroxy-11-hydroxymethyl-12-methy...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of PKM2 (unknown origin) Hie78, Arg73, Thr328 residues by coloroimetric/fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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