Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50014951
TargetATP-dependent translocase ABCB1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581481(CHEMBL5089855)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581480(CHEMBL5088809)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 38nMAssay Description:Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581481(CHEMBL5089855)
Affinity DataIC50: 46nMAssay Description:Inhibition of BCRP in HEK293/R2 cells assessed as reversal of topotecan resistance by measuring topotecan IC50 at 1 uM after 5 days by Cell Titer-Glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581480(CHEMBL5088809)
Affinity DataIC50: 101nMAssay Description:Inhibition of BCRP in HEK293/R2 cells assessed as reversal of topotecan resistance by measuring topotecan IC50 at 1 uM after 5 days by Cell Titer-Glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581480(CHEMBL5088809)
Affinity DataIC50: 341nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance by measuring doxorubicin IC50 at 1 uM after 5 days by Cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581481(CHEMBL5089855)
Affinity DataIC50: 354nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance by measuring doxorubicin IC50 at 1 uM after 5 days by Cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed