Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50018403
TargetWD repeat-containing protein 5(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM468882(US10807959, Example B15)
Affinity DataKd:  1.30nMAssay Description:Inhibition of human WDR5 WIN site expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608076(CHEMBL5281547)
Affinity DataKd:  1.00E+7nMAssay Description:Binding affinity to NSD1 SET domain(1852 to 2085 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase UHRF1(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608078(CHEMBL1876546)
Affinity DataEC50:  4.50E+4nMAssay Description:Inhibition of His tagged UHRF1 tandem Tudor domain (unknown origin) using biotinylated-H3K9me3 peptide as substrate incubated for 1 hr by TR-FRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608073(CHEMBL5280983)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 7(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50157607(CHEMBL3753082 | US11773085, Compound B24)
Affinity DataKd:  909nMAssay Description:Inhibition of BRD7 (unknown origin) by Isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 9(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608072(CHEMBL5267719)
Affinity DataKd:  612nMAssay Description:Inhibition of BRD9 (unknown origin) by Isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50157646(CHEMBL216146)
Affinity DataKd:  5nMAssay Description:Inhibition of BRD9 (unknown origin) by Isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 9(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50157607(CHEMBL3753082 | US11773085, Compound B24)
Affinity DataKd:  99nMAssay Description:Inhibition of BRD9 (unknown origin) by Isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATPase family AAA domain-containing protein 2(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608071(CHEMBL5279678)
Affinity DataKd:  2.40E+6nMAssay Description:Binding affinity to N-terminal GST-ATAD2 bromodomain (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by Isothermal t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608070(CHEMBL5273240)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to BRD2 BD2 (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608070(CHEMBL5273240)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to BRD2 BD1 (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase UHRF1(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608079(CHEMBL5286019)
Affinity DataEC50:  2.90E+4nMAssay Description:Inhibition of His tagged UHRF1 tandem Tudor domain (unknown origin) using biotinylated-H3K9me3 peptide as substrate incubated for 1 hr by TR-FRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50555100(CHEMBL4749457)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to recombinant human NSD3 PWWP1 domain (247 to 398 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50380664(CHEMBL2017287)
Affinity DataKd:  37nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated tetra-acetylated Histone H4 peptide as substrate and measured for 1 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50380664(CHEMBL2017287)
Affinity DataKd:  32nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) using biotinylated tetra-acetylated Histone H4 peptide as substrate and measured for 1 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50380664(CHEMBL2017287)
Affinity DataKd:  39nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) using biotinylated tetra-acetylated Histone H4 peptide as substrate and measured for 1 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608080(CHEMBL5277519)
Affinity DataKd:  1.66E+5nMAssay Description:Binding affinity to recombinant human NSD3 PWWP1 domain (247 to 398 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608081(CHEMBL5270364)
Affinity DataKd:  7.31E+5nMAssay Description:Binding affinity to recombinant human NSD3 PWWP1 domain (247 to 398 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608082(CHEMBL5265919)
Affinity DataKd:  1.60E+5nMAssay Description:Binding affinity to recombinant human NSD3 PWWP1 domain (247 to 398 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetWD repeat-containing protein 5(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608083(CHEMBL5205374)
Affinity DataKd:  6.60E+4nMAssay Description:Inhibition of human WDR5 WIN site expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetWD repeat-containing protein 5(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM468872(US10807959, Example B5)
Affinity DataKd:  22nMAssay Description:Inhibition of human WDR5 WIN site expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 5A(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of KDM5A (unknown origin) using H3K4me3 as substrate by MSD ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 13nMAssay Description:Inhibition of B-Raf V600E mutant (448 to 723 residues) (unknown origin) expressed in Escherichia coli by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608069(CHEMBL5285272)
Affinity DataIC50: 21nMAssay Description:Binding affinity to human CBP/p300 bromodomain using H-ALREIRRYQK(ac)STELLIRKLK(biotin)-OH as substrate incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 160nMAssay Description:Inhibition of B-raf (448 to 723 residues) (unknown origin) expressed in Escherichia coli by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608080(CHEMBL5277519)
Affinity DataIC50: 203nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 5A(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608074(CHEMBL5269002)
Affinity DataIC50: 238nMAssay Description:Inhibition of KDM5A (unknown origin) using H3K4me3 as substrate by MSD ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608069(CHEMBL5285272)
Affinity DataIC50: 850nMAssay Description:Binding affinity to human BRD4 BD1 using H-YSGRGKacGGKacGLGKacGGAKacRHRK(biotin)-OH as substrate incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50353588(CHEMBL1828978)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) using biotin-H4Ac4 as substrate preincubated for 30 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2B(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50398244(CHEMBL609728)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of GST-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using Biotin-GISYGR-AcK-KKR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50353588(CHEMBL1828978)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotin-H4Ac4 as substrate preincubated for 30 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608075(CHEMBL5276207)
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of human N-terminal His-tagged LSD1 using histone H3 peptide (1 to 21 residues) K4me2 as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608076(CHEMBL5281547)
Affinity DataIC50: 6.60E+7nMAssay Description:Inhibition of NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 1 hrs followed by HM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50608077(CHEMBL5270736)
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 1 hrs followed by HM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50353587(CHEMBL12543)
Affinity DataIC50: 6.00E+6nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotin-H4Ac4 as substrate preincubated for 30 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50353587(CHEMBL12543)
Affinity DataIC50: 9.00E+6nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) using biotin-H4Ac4 as substrate preincubated for 30 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50155773(US9469597, 5 | CHEMBL3781751)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant LSD1 using H3K4me2 as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM113742(N-[4-(2-Hydrazinylethyl)phenyl]-4-phenylbutanamide...)
Affinity DataKi:  59nMAssay Description:Inhibition of human recombinant LSD1 using H3K4me2 as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50105417(CHEMBL1089 | Nardil | Phenethyl-hydrazine | PHENEL...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of human recombinant LSD1 using H3K4me2 as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-2-phenylcyclopropanamine | cid_2723716 | (...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of human recombinant LSD1 using H3K4me2 as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed