Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50017525
TargetTyrosine-protein kinase Mer(Mouse)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602486(CHEMBL5196154)
Affinity DataKd:  13nMAssay Description:Binding affinity to MERTK in cuprizone-challenged C57BL/6 mouse whole brain assessed as dissociation constant at 18.1 nM by autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Mer(Mouse)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602486(CHEMBL5196154)
Affinity DataKd:  20nMAssay Description:Binding affinity to MERTK in cuprizone-challenged C57BL/6 mouse brain CC/HC region assessed as dissociation constant at 18.1 nM by autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Mer(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM308131(US9649309, Compound UNC2876A)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of MERTK (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602486(CHEMBL5196154)
Affinity DataIC50: 4nMAssay Description:Inhibition of MERTK (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Mer(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602485(CHEMBL5171919)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of MERTK (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM308131(US9649309, Compound UNC2876A)
Affinity DataIC50: 49nMAssay Description:Inhibition of FLT3 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602486(CHEMBL5196154)
Affinity DataIC50: 110nMAssay Description:Inhibition of FLT3 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602485(CHEMBL5171919)
Affinity DataIC50: 120nMAssay Description:Inhibition of FLT3 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM308131(US9649309, Compound UNC2876A)
Affinity DataIC50: 150nMAssay Description:Inhibition of Tyro3 (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602486(CHEMBL5196154)
Affinity DataIC50: 170nMAssay Description:Inhibition of Axl (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary ele...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602485(CHEMBL5171919)
Affinity DataIC50: 200nMAssay Description:Inhibition of Axl (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary ele...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM308131(US9649309, Compound UNC2876A)
Affinity DataIC50: 218nMAssay Description:Inhibition of Axl (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary ele...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602485(CHEMBL5171919)
Affinity DataIC50: 390nMAssay Description:Inhibition of Tyro3 (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50602486(CHEMBL5196154)
Affinity DataIC50: 400nMAssay Description:Inhibition of Tyro3 (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed