Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50014713
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579388(CHEMBL4877510)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579389(CHEMBL4876875)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in paclitaxel IC50 at 2 uM pre-incubated for 4 hrs followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579389(CHEMBL4876875)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human recombinant CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579389(CHEMBL4876875)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of recombinant human P-gp ATPase activity incubated for 60 mins by luminescence based Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of human recombinant CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579389(CHEMBL4876875)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in paclitaxel IC50 at 1 uM pre-incubated for 4 hrs followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in paclitaxel IC50 at 2 uM pre-incubated for 4 hrs followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579389(CHEMBL4876875)
Affinity DataIC50: 2.22E+4nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in colchicine IC50 at 2 uM pre-incubated for 4 hrs followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579389(CHEMBL4876875)
Affinity DataIC50: 3.05E+4nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in paclitaxel IC50 at 0.5 uM pre-incubated for 4 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579389(CHEMBL4876875)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in colchicine IC50 at 1 uM pre-incubated for 4 hrs followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 1.68E+5nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in colchicine IC50 at 2 uM pre-incubated for 4 hrs followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50579389(CHEMBL4876875)
Affinity DataIC50: 3.21E+5nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in colchicine IC50 at 0.5 uM pre-incubated for 4 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed