Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50015436
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465744(US10793575, Example 19 | 2-{3-[2-amino-6-(pyridin-...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM468316(US10793575, Example 87 | 4-{2-amino-4-[3- (6-cyclo...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM468313(US10793575, Example 71 | 2-(3-{2-amino-6- [1-(4-me...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM468320(US10793575, Example 93 | 2-{3-[2-amino-6-(1,2,3,6-...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM468313(US10793575, Example 71 | 2-(3-{2-amino-6- [1-(4-me...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50586595(CHEMBL5083974)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50586593(CHEMBL5076374)
Affinity DataIC50: 0.710nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM468316(US10793575, Example 87 | 4-{2-amino-4-[3- (6-cyclo...)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction of IgM stimulated PLCgamma2 (Y1217) phosphorylation after 24 hrs by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM468320(US10793575, Example 93 | 2-{3-[2-amino-6-(1,2,3,6-...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type BTK (unknown origin) in presence of 1 mM ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in BTK phosphorylation at Tyr223 residue incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human TEC (359 - 631 residues) expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in BTK phosphorylation at Tyr223 residue incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction of IgM stimulated PLCgamma2 (Y1217) phosphorylation after 24 hrs by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465742(US10793575, Example 17 | 2-{3-[2-amino-6-(pyridin-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50586594(CHEMBL5082144)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of wild type BTK (unknown origin) in presence of 1 mM ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of BTK C481S mutant (unknown origin) in presence of 1 mM ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of BTK in human whole blood assessed as activation of anti-IgM-induced CD69 expression by flow cytometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human full-length BMX (1 to 675 residues) expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 11nMAssay Description:Inhibition of BTK in human whole blood assessed as activation of anti-IgM-induced CD69 expression by flow cytometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BTK C481S mutant (unknown origin) in presence of 1 mM ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465726(US10793575, Example 1 | 2-[3-(2-amino-6-phenyl-7H-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465732(US10793575, Example 7 | 2-[3-(2-amino-6-methyl- 7H...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465731(US10793575, Example 6 | 2-[3-(2-amino-7H-pyrrolo[2...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 61nMAssay Description:Inhibition of human ITK (2 - 620 residues) expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 221nMAssay Description:Inhibition of human DDR1 (444 - 876 residues) expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 291nMAssay Description:Inhibition of human full length SRC expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 306nMAssay Description:Inhibition of human MUSK expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 3.17E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 5.38E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 8.54E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2CD6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed