Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50015022
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM532292(JGS79C | N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-m...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full length TTK (unknown origin) using MBP-derived peptide as substrate preincubated for 1 hr in dark followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582063(CHEMBL5092826)
Affinity DataIC50: 1nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582067(CHEMBL5093015)
Affinity DataIC50: 1nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582061(CHEMBL5081270)
Affinity DataIC50: 2nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582065(CHEMBL5075313)
Affinity DataIC50: 2nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582068(CHEMBL5077668)
Affinity DataIC50: 2nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582069(CHEMBL5073101)
Affinity DataIC50: 2nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582074(CHEMBL5081668)
Affinity DataIC50: 2.80nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582064(CHEMBL5091689)
Affinity DataIC50: 3nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582066(CHEMBL5084062)
Affinity DataIC50: 3nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 3nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582070(CHEMBL5085278)
Affinity DataIC50: 4nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582071(CHEMBL5086022)
Affinity DataIC50: 4nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582076(CHEMBL5079606)
Affinity DataIC50: 5.30nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582075(CHEMBL5085182)
Affinity DataIC50: 5.60nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582062(CHEMBL5086435)
Affinity DataIC50: 6nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582073(CHEMBL5077627)
Affinity DataIC50: 7.5nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582072(CHEMBL5087340)
Affinity DataIC50: 9nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetTestis-specific serine/threonine-protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 35nMAssay Description:Inhibition of TSSK1 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 74nMAssay Description:Inhibition of TTK autophosphorylation at T686 residue in human CAL-51 cells measured after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 192nMAssay Description:Inhibition of JNK1 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 229nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin) by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM317462(US9623028, Compound 38 | 4-(4-(cyclopentyloxy)-5-(...)
Affinity DataIC50: 280nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 342nMAssay Description:Inhibition of LRRK2 (unknown origin) by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 545nMAssay Description:Inhibition of CHK2 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 602nMAssay Description:Inhibition of JNK2 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetTestis-specific serine/threonine-protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 944nMAssay Description:Inhibition of TSSK2 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582067(CHEMBL5093015)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of SRC N1 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of MAPKAPK3 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582065(CHEMBL5075313)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582061(CHEMBL5081270)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582069(CHEMBL5073101)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582076(CHEMBL5079606)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50512317(CHEMBL4569626)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582062(CHEMBL5086435)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582066(CHEMBL5084062)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582075(CHEMBL5085182)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582074(CHEMBL5081668)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582073(CHEMBL5077627)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582071(CHEMBL5086022)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582070(CHEMBL5085278)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582068(CHEMBL5077668)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 3.00E+4nMAssay Description:Time dependent inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed