Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with all data for entry = 50018281
TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50075071(CHEMBL3414619)
Affinity DataIC50: 10nMAssay Description:Inhibition of EZH2 (unknown origin) in PRC2 complex using H3 (1 to 24 residues) and 3H-SAM as substrate incubated for 1 hrs by Scintillation proximit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50075071(CHEMBL3414619)
Affinity DataIC50: 124nMAssay Description:Inhibition of human EZH2 in human MCF-10A cells assessed as reduction in H3K27me3 levels incubated for 72 hrs by In-cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of GST-tagged full length human G9a (685 to 1000 residues) methylation activity expressed in Escherichia coli BL21 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed