Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50014143
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Activity at human wild type PRMT5/HA-tagged WDR77 hetero octameric complex expressed in HEK293 (Expi293) cells assessed as PRMT5 adduct formation inc...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Disruption of human N-terminal SmBiT peptide-tagged PRMT5/ N-terminal LgBiT tagged RIOK1 complex expressed in permeabilized HEK293T cells by NanoBiT ...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 5.40E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 6.10E+3nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 7.50E+3nMAssay Description:Disruption of human N-terminal SmBiT peptide-tagged PRMT5/ N-terminal LgBiT tagged RIOK1 complex expressed in permeabilized HEK293T cells by NanoBiT ...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.01E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.24E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.27E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.38E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.41E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.92E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.33E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 3.17E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 3.56E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 3.90E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 5.54E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 7.21E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 7.29E+4nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
3D Structure (crystal)TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells measured up to 4 hrs at10 mins time ...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataKi: 8.00E+3nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataKi: 1.90E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataKi: 3.60E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataKi: 4.20E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataKi: 4.90E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataKi: 5.80E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
The Broad Institute of Mit and Harvard
Curated by ChEMBL
The Broad Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataKi: 7.80E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
