Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with all data for entry = 50013505
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301220(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301220(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301220(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301243(3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566789(CHEMBL4862283)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301192(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50566796(CHEMBL4871581)
Affinity DataIC50: 1nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301216(3-(2-Fluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301192(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301192(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50566796(CHEMBL4871581)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of VEGFR2 (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301191(3-(2-Chloro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301216(3-(2-Fluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301216(3-(2-Fluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301261(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,3-difluo...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301191(3-(2-Chloro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301191(3-(2-Chloro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566796(CHEMBL4871581)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of AURKB (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50566796(CHEMBL4871581)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of c-KIT (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566791(CHEMBL4874869)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50566796(CHEMBL4871581)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of PDGFR-beta (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566789(CHEMBL4862283)
Affinity DataIC50: 6nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301306(4-[3-(2,6-difluoro-3,5-dimethoxyphenyl)-2,8-dioxo-...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566794(CHEMBL4858423)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of c-KIT (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566793(CHEMBL4848530)
Affinity DataIC50: 20nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566795(CHEMBL4873003)
Affinity DataIC50: 21nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Mouse)
Incyte

Curated by ChEMBL
LigandPNGBDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 22nMAssay Description:In vivo inhibition of FGFR2 in po dosed SCID mouse xenografted with human KATO III stomach cancer cell line administered as single dose and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566792(CHEMBL4866178)
Affinity DataIC50: 27nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301220(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301193(3-(2,4-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 82nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50566790(CHEMBL4861534)
Affinity DataIC50: 83nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301216(3-(2-Fluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301193(3-(2,4-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 97nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM301193(3-(2,4-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 108nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301191(3-(2-Chloro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50: 131nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301192(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 162nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301233(BDBM301247 | US10131667, Example 49 | 3-(2,6-Diflu...)
Affinity DataIC50: 288nMAssay Description:Inhibition of VEGFR2 (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 406nMAssay Description:Inhibition of PDGFR-beta (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301233(BDBM301247 | US10131667, Example 49 | 3-(2,6-Diflu...)
Affinity DataIC50: 407nMAssay Description:Inhibition of c-KIT (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301023(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Affinity DataIC50: 452nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 458nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50566790(CHEMBL4861534)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
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