Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50014134
TargetDiacylglycerol O-acyltransferase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM504493(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of DGAT2 in human hepatocytes using [14C]-glycerol as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM504500(2-{5-[(3-ethoxy-5-fluoropyridin-2- yl)oxy]pyridin-...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of DGAT2 in human hepatocytes using [14C]-glycerol as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM504424(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of DGAT2 in human hepatocytes using [14C]-glycerol as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 11nMAssay Description:Inhibition of DGAT2 in human hepatocytes using [14C]-glycerol as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM504505(US11065249, Example 19 | First-eluting enantiomer ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of DGAT2 in human hepatocytes using [14C]-glycerol as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM504482(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 23nMAssay Description:Inhibition of DGAT2 in human hepatocytes using [14C]-glycerol as substrate preincubated for 15 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed