Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50014598
Target5-hydroxytryptamine receptor 1A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of 5-HT1a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264120(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of 5-HT1a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264118(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264118(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of 5-HT1a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264120(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264098(3-(3-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264101(3-(5-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264096(3-(4-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of 5-HT1a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264104(3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264105(3-(3-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM50577834(CHEMBL4877630)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264100(3-(2-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264107(3-(5-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM50577833(CHEMBL4866826)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264121(3-(3-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264116(3-(4-(4-(4-(1-oxoisoquinolin-2(1H)-yl)phenyl)piper...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264109(3-(3-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264111(3-(5-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM50577835(CHEMBL4854319)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM50577832(CHEMBL4876897)
Affinity DataIC50: 6nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264108(3-(4-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264106(3-(2-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264117(3-(3-(4-(4-(1-oxoisoquinolin-2(1H)-yl)phenyl)piper...)
Affinity DataIC50: 10nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264110(3-(2-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Affinity DataIC50: 12nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT2a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264118(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT2a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264120(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT2a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT2c (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264118(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT2c (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264120(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT2c (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264119(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264118(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264120(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-HT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed