Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50014871
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580568(CHEMBL5088115)
Affinity DataEC50:  8.30E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)
Affinity DataKd:  500nMAssay Description:Binding affinity to TLX LBD expressed in His6-tagged Escherichia coli Rosetta assessed as binding constant measured after 300 sec at 200 mM by isothe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)
Affinity DataEC50:  3.70E+4nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580566(CHEMBL3304960)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50404775(CHEMBL31888)
Affinity DataEC50:  4.30E+4nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50130262(2,3,4,9-Tetrahydro-1H-beta-carboline | CHEMBL26923...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)
Affinity DataEC50:  3.20E+4nMAssay Description:Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as dec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50061966(Isopropyl-[3-(naphthalen-1-yloxy)-propyl]-amine | ...)
Affinity DataEC50:  5.00E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580569(CHEMBL5083628)
Affinity DataEC50:  5.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50130262(2,3,4,9-Tetrahydro-1H-beta-carboline | CHEMBL26923...)
Affinity DataEC50:  7.40E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580567(CHEMBL5070124)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246936(S-(-)-propanolol | (-)-(S)-Propranolol | [2-Hydrox...)
Affinity DataEC50:  7.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM60973(MLS001333595 | (2R)-1-(1-naphthalenyloxy)-3-(propa...)
Affinity DataEC50:  4.00E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50067133(CHEMBL631 | 1-[2-(2-Hydroxy-3-propylamino-propoxy)...)
Affinity DataEC50:  4.70E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)
Affinity DataEC50:  3.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580566(CHEMBL3304960)
Affinity DataEC50:  6.70E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50404775(CHEMBL31888)
Affinity DataEC50:  1.94E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed