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Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50013640
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM225238(BTK inhibitor, 3)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of recombinant wild type human N-terminal His6-tagged BTK expressed in baculovirus incubated for 20 mins by TR-FRET based competitive bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM225238(BTK inhibitor, 3)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK C481S mutant expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM225238(BTK inhibitor, 3)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568217(CHEMBL4866645)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568217(CHEMBL4866645)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK C481S mutant expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568221(CHEMBL4854947)
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568222(CHEMBL4867490)
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568220(CHEMBL4873655)
Affinity DataIC50: 232nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568218(CHEMBL4859382)
Affinity DataIC50: 4.76E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568222(CHEMBL4867490)
Affinity DataIC50: 5.92E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK C481S mutant expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568221(CHEMBL4854947)
Affinity DataIC50: 5.92E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK C481S mutant expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568220(CHEMBL4873655)
Affinity DataIC50: 5.92E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK C481S mutant expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568219(CHEMBL4861473)
Affinity DataIC50: 5.92E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK C481S mutant expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568218(CHEMBL4859382)
Affinity DataIC50: 5.92E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK C481S mutant expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568219(CHEMBL4861473)
Affinity DataIC50: 3.64E+4nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568221(CHEMBL4854947)
Affinity DataKi:  1.25E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells assessed as inhibitory constant incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568222(CHEMBL4867490)
Affinity DataKi:  1.93E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells assessed as inhibitory constant incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568220(CHEMBL4873655)
Affinity DataKi:  9.27E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells assessed as inhibitory constant incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed