Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50011695
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  890nMAssay Description:Binding affinity to recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  870nMAssay Description:Binding affinity to recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  340nMAssay Description:Binding affinity to full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  220nMAssay Description:Binding affinity to full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  140nMAssay Description:Binding affinity to RIOK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 520nMAssay Description:Inhibition of full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550132(CHEMBL4749658)
Affinity DataIC50: 780nMAssay Description:Inhibition of full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 860nMAssay Description:Inhibition of recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550129(CHEMBL4744511)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550132(CHEMBL4749658)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550133(CHEMBL4754518)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550129(CHEMBL4744511)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550133(CHEMBL4754518)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550129(CHEMBL4744511)
Affinity DataIC50: 5.20E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550132(CHEMBL4749658)
Affinity DataIC50: 5.20E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550137(CHEMBL4750817)
Affinity DataIC50: 5.30E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550133(CHEMBL4754518)
Affinity DataIC50: 6.60E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550128(CHEMBL4777902)
Affinity DataIC50: 7.50E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550134(CHEMBL4748932)
Affinity DataIC50: 7.60E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550142(CHEMBL4799148)
Affinity DataIC50: 7.60E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550132(CHEMBL4749658)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550133(CHEMBL4754518)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550132(CHEMBL4749658)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550129(CHEMBL4744511)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550133(CHEMBL4754518)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550133(CHEMBL4754518)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550129(CHEMBL4744511)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550129(CHEMBL4744511)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550132(CHEMBL4749658)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550130(CHEMBL4785960)
Affinity DataIC50: 1.34E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550138(CHEMBL4749115)
Affinity DataIC50: 1.45E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.46E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550139(CHEMBL4786052)
Affinity DataIC50: 2.80E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550140(CHEMBL4745254)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550141(CHEMBL4791951)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550136(CHEMBL4765173)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550135(CHEMBL4794407)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed