Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 50013623
TargetSodium channel protein type 2 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Nav1.2 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of late channel current at holding potential of -95 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 18nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of peak channel current at holding potential of -95 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568139(CHEMBL4864812)
Affinity DataIC50: 31nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 39nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 44nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 65nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 65nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 90nMAssay Description:Inhibition of human Nav1.1 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Nav1.6 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Nav1.5 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 220nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by sodium flux analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 230nMAssay Description:Inhibition of human Nav1.6 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568135(CHEMBL4849813)
Affinity DataIC50: 240nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568135(CHEMBL4849813)
Affinity DataIC50: 240nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568134(CHEMBL4863095)
Affinity DataIC50: 260nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 270nMAssay Description:Inhibition of human Nav1.2 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 270nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568120(CHEMBL4859414)
Affinity DataIC50: 410nMAssay Description:Inhibition of human Nav1.5 VSD2 R814A mutant by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568131(CHEMBL4853170)
Affinity DataIC50: 460nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568133(CHEMBL4860097)
Affinity DataIC50: 470nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 560nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568132(CHEMBL4865860)
Affinity DataIC50: 610nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 620nMAssay Description:Inhibition of human Nav1.1 by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568130(CHEMBL4876448)
Affinity DataIC50: 680nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568120(CHEMBL4859414)
Affinity DataIC50: 700nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568141(CHEMBL4872374)
Affinity DataIC50: 750nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568122(CHEMBL4867480)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568117(CHEMBL4867340)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568121(CHEMBL4870820)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568140(CHEMBL4850129)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117271(CHEMBL558 | 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethy...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin)-mediated late channel currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568126(CHEMBL4850942)
Affinity DataIC50: 4.32E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568136(CHEMBL4862429)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568124(CHEMBL4846327)
Affinity DataIC50: 4.65E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568127(CHEMBL4863596)
Affinity DataIC50: 5.04E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568129(CHEMBL4855375)
Affinity DataIC50: 6.33E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568135(CHEMBL4849813)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50173335(CHEBI:87690 | CVT-303 | RS-43285-003 | Ranexa | Ra...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin)-mediated late channel currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568118(CHEMBL4877705)
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568116(CHEMBL4867251)
Affinity DataIC50: 7.83E+3nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568128(CHEMBL4857167)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568123(CHEMBL4849208)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568119(CHEMBL4862578)
Affinity DataIC50: 2.55E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568125(CHEMBL4872687)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568137(CHEMBL4865549)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.5 by automated voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataKi:  370nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568135(CHEMBL4849813)
Affinity DataKi:  2.02E+3nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed