Compile Data Set for Download or QSAR
Report error Found 168 Enz. Inhib. hit(s) with all data for entry = 50014524
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged MERTK (528 to 999 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of N-terminal GST-tagged MERTK (528 to 999 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497276((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497268((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497291((4-(2-(butylamino)-7- ((1r,4r)-4- hydroxycyclohexy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497260((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497277((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497259((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497285((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497253((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497288((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of N-terminal GST-tagged MELK (1 to 493 residues) (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497312((1S,4r)-4-(5-(1-((2,6- dimethylpyridin-4- yl)methy...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal GST-tagged FLT3 (564 to 993 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50577089(CHEMBL4850498)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal GST-tagged HGK (1 to 328 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497237((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497262((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497294((4-(2-(benzylamino)-7- ((1r,4r)-4- hydroxycyclohex...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497238((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of N-terminal GST-tagged TYRO3 (453 to 890 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497261((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of N-terminal GST-tagged FLT3 (564 to 993 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of N-terminal GST-tagged TRKA (436 to 790 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497274((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50577090(CHEMBL4862062)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497279((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497295((2,6-dimethylpyridin-4- yl)(4-(7-((1r,4S)-4- hydro...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497229((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- ((tet...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497272((1S,4R)-4-(5-([1,4'- bipiperidin]-4-yl)-2-(((S)- p...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497287((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497320((1S,4r)-4-(2-(((S)-pentan-2- yl)amino)-5-(pyrrolid...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497289((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of N-terminal GST-tagged TNIK (1 to 314 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497297((4-(2- ((cyclohexylmethyl)amino)- 7-((1r,4r)-4- hy...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497286((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497284((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497291((4-(2-(butylamino)-7- ((1r,4r)-4- hydroxycyclohexy...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50577091(CHEMBL4848248)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497232((1S,4R)-4-(5-(1- (methylsulfonyl)piperidin- 4-yl)-...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of N-terminal GST-tagged TRKC (456 to 825 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497292((3,5-dimethylphenyl)(4-(7- ((1r,4S)-4- hydroxycycl...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of MERTK in human 697 cells assessed as reduction in phosphorylation of MERTK preincubated for 1 hr followed by vanadate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497300((4- (dimethylamino)phenyl)(4- (7-((1r,4S)-4- hydro...)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged AXL (464 to 885 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497298((4-(2-(((R)-2,3-dihydro-1H- inden-1-yl)amino)-7- (...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal GST-tagged TYRO3 (453 to 890 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497259((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: 18nMAssay Description:Inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497276((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)
Affinity DataIC50: 21nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
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