Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50015625
TargetStimulator of interferon genes protein(Human)
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataKd: 53nMAssay Description:Binding affinity to wild-type human STING CTD (149 to 379 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by iso...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at TLR7 in human PBMC incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at R848 stimulated TRL8 overexpressed in HEK293 cells measured after 20 to 24 hrs by SEAP reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at R848 stimulated TRL8 overexpressed in HEK293 cells measured after 20 to 24 hrs by SEAP reporter assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta level incubated for 1 hr followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at TLR9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Antagonist activity at TLR8 in human PBMC incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of full length human cGAS expressed in Escherichia coli BL21 (DE3) incubated for 2 hrs in presence of ATP by RF-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Antagonist activity at R848 stimulated TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated with comp...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Antagonist activity at R848 stimulated TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated with comp...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Antagonist activity at R848 stimulated TRL9 in HEK-Blue hTLR9 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Antagonist activity at R848 stimulated TRL9 in HEK-Blue hTLR9 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Antagonist activity at R848 stimulated TRL8 overexpressed in HEK293 cells measured after 20 to 24 hrs by SEAP reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of full length human cGAS expressed in Escherichia coli BL21 (DE3) incubated for 2 hrs in presence of ATP by RF-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of human cGAS expressed in human THP-1 cells transfected with HT-DNA incubated for 20 mins in presence of ATP by luminescence based analys...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Antagonist activity at TLR9 in human PBMC incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 391nMAssay Description:Inhibition of full-length human cGAS by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length human cGAS by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of N-terminal 6XHis-SUMO2 fused full length human cGAS (1 to 522 residues) expressed in human THP-1 cells transfected with HT-DNA incubate...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta level incubated for 1 hr followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+3nMAssay Description:Antagonist activity at R848 stimulated TRL9 in HEK-Blue hTLR9 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of cGAS expressed in human THP-1 cells assessed as reduction of IFN-beta expression by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of N-terminal 6XHis-SUMO2 fused full length human cGAS (1 to 522 residues) expressed in human THP-1 cells transfected with HT-DNA incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Antagonist activity at R848 stimulated TRL9 in HEK-Blue hTLR9 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at N-terminal 6XHis tagged human cGAS (155 to 522 residues) expressed in Escherichia coli BL21 DE3 Rosetta 2 in presence of ATP b...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed C57BL/6 mouse bone marrow derived macrophages incubated for 30 mins in presence of ATP by i...More data for this Ligand-Target Pair
Affinity DataIC50: 2.99E+4nMAssay Description:Inhibition of N-terminal 6XHis-SUMO2 fused full length human cGAS (1 to 522 residues) expressed in human THP-1 cells transfected with HT-DNA incubate...More data for this Ligand-Target Pair
