Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50014433
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576171(CHEMBL4875567)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576163(CHEMBL4864019)
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576166(CHEMBL4861143)
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576165(CHEMBL4875540)
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576164(CHEMBL4869726)
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576162(CHEMBL4849233)
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576168(CHEMBL4855155)
Affinity DataIC50: 18nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576169(CHEMBL4865557)
Affinity DataIC50: 24nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576167(CHEMBL4862057)
Affinity DataIC50: 25nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576162(CHEMBL4849233)
Affinity DataIC50: 36nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576170(CHEMBL4858170)
Affinity DataIC50: 38nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576169(CHEMBL4865557)
Affinity DataIC50: 54nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 20 % FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576165(CHEMBL4875540)
Affinity DataIC50: 58nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576169(CHEMBL4865557)
Affinity DataIC50: 82nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 50 % FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576168(CHEMBL4855155)
Affinity DataIC50: 109nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 20 % FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576168(CHEMBL4855155)
Affinity DataIC50: 167nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 50 % FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576165(CHEMBL4875540)
Affinity DataIC50: 8.35E+3nMAssay Description:Inhibition of human NTCP residues (157 to 165) replaced with monkey NTCP -mediated [3H]-TCA uptake expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576167(CHEMBL4862057)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 20 % FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium/bile acid cotransporter(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50576167(CHEMBL4862057)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 50 % FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed