Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50015066
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582443(CHEMBL5077087)
Affinity DataEC50:  3.40E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582435(CHEMBL4762823)
Affinity DataEC50:  1.60E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582436(CHEMBL5078513)
Affinity DataEC50:  5.50E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582437(CHEMBL4781329)
Affinity DataEC50:  9.50E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582438(CHEMBL4789388)
Affinity DataEC50:  6.10E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582439(CHEMBL5078045)
Affinity DataEC50:  2.70E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582440(CHEMBL5080655)
Affinity DataEC50:  3.00E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582441(CHEMBL5076483)
Affinity DataEC50:  2.70E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582442(CHEMBL5075475)
Affinity DataEC50:  9.60E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582419(CHEMBL3719424)
Affinity DataEC50:  1.40E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582444(CHEMBL5081373)
Affinity DataEC50:  1.00E+5nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582445(CHEMBL5073447)
Affinity DataEC50:  8.90E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582446(CHEMBL5081096)
Affinity DataEC50:  6.50E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582447(CHEMBL5077658)
Affinity DataEC50:  1.58E+5nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582448(CHEMBL5074623)
Affinity DataEC50:  4.30E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582449(CHEMBL5093828)
Affinity DataEC50:  3.40E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582450(CHEMBL4778540)
Affinity DataEC50:  3.80E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582433(CHEMBL4763822)
Affinity DataEC50:  5.10E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582434(CHEMBL5085738)
Affinity DataEC50:  2.90E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582418(CHEMBL1542875)
Affinity DataEC50:  4.30E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582420(CHEMBL3719434)
Affinity DataEC50:  2.10E+3nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582421(CHEMBL5074001)
Affinity DataEC50:  1.60E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582422(CHEMBL3719410)
Affinity DataEC50:  4.10E+3nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582423(CHEMBL5079685)
Affinity DataEC50:  1.20E+3nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582424(CHEMBL5094307)
Affinity DataEC50:  174nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582425(CHEMBL5077335)
Affinity DataEC50:  90nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582426(CHEMBL3719411)
Affinity DataEC50:  55nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582427(CHEMBL3719486)
Affinity DataEC50:  53nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582428(CHEMBL3719416)
Affinity DataEC50:  2.90E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582429(CHEMBL3719536)
Affinity DataEC50:  1.51E+5nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582430(CHEMBL4598390)
Affinity DataEC50:  3.90E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582431(CHEMBL4756097)
Affinity DataEC50:  2.90E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetG-protein coupled receptor 6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582432(CHEMBL5080739)
Affinity DataEC50:  2.10E+4nMAssay Description:Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582430(CHEMBL4598390)
Affinity DataIC50: 50nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582429(CHEMBL3719536)
Affinity DataIC50: 126nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582441(CHEMBL5076483)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin) over CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582450(CHEMBL4778540)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582431(CHEMBL4756097)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582438(CHEMBL4789388)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582439(CHEMBL5078045)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582433(CHEMBL4763822)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582449(CHEMBL5093828)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582444(CHEMBL5081373)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582449(CHEMBL5093828)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582435(CHEMBL4762823)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582443(CHEMBL5077087)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582437(CHEMBL4781329)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582434(CHEMBL5085738)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582447(CHEMBL5077658)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50582445(CHEMBL5073447)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
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