Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50012432
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50280402(CHEBI:17737 | 24-Dehydrocholesterol | Desmosterol)
Affinity DataEC50:  48nMAssay Description:Orthosteric agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Escherich...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM20175((1S,2R,5S,10S,11S,14S,15S)-14-[(2S)-2-hydroxy-6-me...)
Affinity DataEC50:  27nMAssay Description:Orthosteric agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Escherich...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM20192((1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-...)
Affinity DataEC50:  418nMAssay Description:Orthosteric agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Escherich...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataIC50: 1.30nMAssay Description:Allosteric inverse agonist activity at 2-chloro-5-nitro-N-(2-(trifluoromethyl)phenyl)benzamide-ligated recombinant human N-terminal His6-tagged RORga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataIC50: 5.5nMAssay Description:Allosteric inverse agonist activity at 2-chloro-N-(2,6-dimethylphenyl)-5-nitrobenzamide-ligated recombinant human N-terminal His6-tagged RORgammat li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataIC50: 5.5nMAssay Description:Allosteric inverse agonist activity at 2-chloro-5-nitro-N-o-tolylbenzamide-ligated recombinant human N-terminal His6-tagged RORgammat ligand binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataIC50: 17nMAssay Description:Allosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519883(CHEMBL4522217)
Affinity DataIC50: 40nMAssay Description:Allosteric inverse agonist activity at 2-chloro-N-(2,6-dimethylphenyl)-5-nitrobenzamide-ligated recombinant human N-terminal His6-tagged RORgammat li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557589(CHEMBL4791369)
Affinity DataIC50: 67nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519883(CHEMBL4522217)
Affinity DataIC50: 68nMAssay Description:Allosteric inverse agonist activity at 2-chloro-5-nitro-N-(2-(trifluoromethyl)phenyl)benzamide-ligated recombinant human N-terminal His6-tagged RORga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557584(CHEMBL4799590)
Affinity DataIC50: 77nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519883(CHEMBL4522217)
Affinity DataIC50: 80nMAssay Description:Allosteric inverse agonist activity at 2-chloro-5-nitro-N-o-tolylbenzamide-ligated recombinant human N-terminal His6-tagged RORgammat ligand binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557587(CHEMBL4793754)
Affinity DataIC50: 81nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM55936(cid_644213 | SMR000326735 | 2-chloranyl-5-nitro-N-...)
Affinity DataIC50: 86nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557590(CHEMBL4790576)
Affinity DataIC50: 89nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557588(CHEMBL4784120)
Affinity DataIC50: 94nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557586(CHEMBL4779012)
Affinity DataIC50: 108nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557585(CHEMBL4740894)
Affinity DataIC50: 122nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557593(CHEMBL229948)
Affinity DataIC50: 131nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557592(CHEMBL4791019)
Affinity DataIC50: 404nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519883(CHEMBL4522217)
Affinity DataIC50: 428nMAssay Description:Allosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50557591(CHEMBL4763539)
Affinity DataIC50: 1.08E+3nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataIC50: 2.31E+3nMAssay Description:Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataIC50: 1.00E+4nMAssay Description:Orthosteric inverse agonist activity at 2-chloro-5-nitro-N-o-tolylbenzamide-ligated recombinant human N-terminal His6-tagged RORgammat ligand binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataIC50: 1.00E+4nMAssay Description:Orthosteric inverse agonist activity at 2-chloro-N-(2,6-dimethylphenyl)-5-nitrobenzamide-ligated recombinant human N-terminal His6-tagged RORgammat l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataIC50: 1.00E+4nMAssay Description:Orthosteric inverse agonist activity at 2-chloro-5-nitro-N-(2-(trifluoromethyl)phenyl)benzamide-ligated recombinant human N-terminal His6-tagged RORg...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)