Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50012429
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557569(CHEMBL4759798)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557568(CHEMBL4790375)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557569(CHEMBL4759798)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557570(CHEMBL4761741)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557564(CHEMBL4783397)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557570(CHEMBL4761741)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557564(CHEMBL4783397)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557566(CHEMBL4741259)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557568(CHEMBL4790375)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557566(CHEMBL4741259)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557565(CHEMBL4755197)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557565(CHEMBL4755197)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataIC50: 11nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557570(CHEMBL4761741)
Affinity DataIC50: 80nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557569(CHEMBL4759798)
Affinity DataIC50: 107nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557565(CHEMBL4755197)
Affinity DataIC50: 460nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557564(CHEMBL4783397)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557568(CHEMBL4790375)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557566(CHEMBL4741259)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557565(CHEMBL4755197)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557570(CHEMBL4761741)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557569(CHEMBL4759798)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557568(CHEMBL4790375)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557566(CHEMBL4741259)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557564(CHEMBL4783397)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataKi:  880nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557564(CHEMBL4783397)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557566(CHEMBL4741259)
Affinity DataKi:  5.15E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557565(CHEMBL4755197)
Affinity DataKi:  8.03E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557570(CHEMBL4761741)
Affinity DataKi:  8.37E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataKi:  9.48E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557568(CHEMBL4790375)
Affinity DataKi:  1.45E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557569(CHEMBL4759798)
Affinity DataKi:  1.98E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataKi:  2.47E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50027656(CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed