Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50012425
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50557557(CHEMBL504910)
Affinity DataKd:  1.53E+4nMAssay Description:Binding affinity to C-terminal His6-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 20 mins by Red-N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50378034(NSC-287088 | PHYSALIN B | CHEMBL504404)
Affinity DataKd:  4.53E+4nMAssay Description:Binding affinity to C-terminal His6-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 20 mins by Red-N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50557557(CHEMBL504910)
Affinity DataIC50: 630nMAssay Description:Inhibition of C-terminal His6-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE) using alpha-ketoglutarate as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50378034(NSC-287088 | PHYSALIN B | CHEMBL504404)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of C-terminal His6-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 (DE) using alpha-ketoglutarate as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50557557(CHEMBL504910)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of wild-type IDH1 (unknown origin) in presence of sodium(D)-isocitrate and NADP+More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50378034(NSC-287088 | PHYSALIN B | CHEMBL504404)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of wild-type IDH1 (unknown origin) in presence of sodium(D)-isocitrate and NADP+More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed