Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50013873
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM47353(US9687494, 25 | BDBM143220 | US9029362, 173)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM47353(US9687494, 25 | BDBM143220 | US9029362, 173)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Mouse)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570460(CHEMBL4854629)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of BACE2 in mouse MIN6 cells expressing wild type TMEM27 assessed as reduction in TMEM27 secretion by MSD electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570460(CHEMBL4854629)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type APP assessed as reduction in amyloid beta 42 level incubated for 18 hrs by AlphaLISA A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570459(CHEMBL4864591)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570459(CHEMBL4864591)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type APP assessed as reduction in amyloid beta 42 level incubated for 18 hrs by AlphaLISA A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570460(CHEMBL4854629)
Affinity DataIC50: 24nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50432609(CHEMBL2347203 | US8999980, I-6)
Affinity DataIC50: 32nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570458(CHEMBL4856391)
Affinity DataIC50: 48nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type APP assessed as reduction in amyloid beta 42 level incubated for 18 hrs by AlphaLISA A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570457(CHEMBL4852444)
Affinity DataIC50: 71nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570458(CHEMBL4856391)
Affinity DataIC50: 145nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50432609(CHEMBL2347203 | US8999980, I-6)
Affinity DataIC50: 166nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570459(CHEMBL4864591)
Affinity DataIC50: 631nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570457(CHEMBL4852444)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570460(CHEMBL4854629)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570458(CHEMBL4856391)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570460(CHEMBL4854629)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]-JNJ962 from BACE1 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50570460(CHEMBL4854629)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]-JNJ962 from BACE2 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed