Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50006137
LigandPNGBDBM50230549(CHEMBL5283010)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human recombinant CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
LigandPNGBDBM50230548(CHEMBL5275131)
Affinity DataEC50:  135nMAssay Description:Agonist activity at human recombinant CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50230547(CHEMBL5290620)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human recombinant CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50230546(CHEMBL5287429)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human recombinant CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
LigandPNGBDBM50230545(CHEMBL5290082)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human recombinant CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230550(CHEMBL5268799)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230550(CHEMBL5268799)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50166256(5-[4-(4-Bromo-phenoxy)-phenyl]-5-(4-isopropyl-pipe...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of beta5 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of beta5 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of beta5 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230543(CHEMBL5283576)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of beta5 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50398607(ONX 0912 | OPROZOMIB | US10640533, Identification ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of beta5 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50093572(CHEMBL3585766)
Affinity DataIC50: 3nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of beta5 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target72 kDa type IV collagenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230552(CHEMBL5267731)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230551(CHEMBL5281153)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230551(CHEMBL5281153)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50: 5nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetCathepsin K(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50095487(Cyclohexanecarboxylic acid (1-cyano-azetidin-3-ylm...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 6nMAssay Description:Inhibition of beta5 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50095487(Cyclohexanecarboxylic acid (1-cyano-azetidin-3-ylm...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230543(CHEMBL5283576)
Affinity DataIC50: 8nMAssay Description:Inhibition of beta2 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 24nMAssay Description:Inhibition of beta 1 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50166256(5-[4-(4-Bromo-phenoxy)-phenyl]-5-(4-isopropyl-pipe...)
Affinity DataIC50: 26nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50264809(Thiirane, 1 | Thiirane (deuterium), 1-d2 | CHEMBL4...)
Affinity DataIC50: 28nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 31nMAssay Description:Inhibition of beta 1 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target72 kDa type IV collagenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50093572(CHEMBL3585766)
Affinity DataIC50: 33nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230543(CHEMBL5283576)
Affinity DataIC50: 33nMAssay Description:Inhibition of beta 1 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230552(CHEMBL5267731)
Affinity DataIC50: 36nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230544(CHEMBL5269437)
Affinity DataIC50: 47nMAssay Description:Inhibition of beta5 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 120nMAssay Description:Inhibition of beta 1 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50095487(Cyclohexanecarboxylic acid (1-cyano-azetidin-3-ylm...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50264809(Thiirane, 1 | Thiirane (deuterium), 1-d2 | CHEMBL4...)
Affinity DataIC50: 400nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of beta2 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of beta2 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of beta 1 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of beta2 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of beta2 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetCathepsin B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230555(CHEMBL5267078)
Affinity DataKi:  2nMAssay Description:Binding affinity to Cathepsin B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetCathepsin B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230554(CHEMBL5283523)
Affinity DataKi:  9.40nMAssay Description:Binding affinity to Cathepsin B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50230554(CHEMBL5283523)
Affinity DataKi:  13nMAssay Description:Binding affinity to Cathepsin L (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed