Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50018236
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50594962(CHEMBL5177178)
Affinity DataKd:  1.40E+5nMAssay Description:Binding affinity to human LSD1 (172 to 833 residues) expressed in Escherichia coli Rosetta 2 strain assessed as binding constant by SPR biosensor ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  243nMAssay Description:Inhibition of human LSD1/CoREST expressed in Escherichia coli using histone H3K4me peptide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407800(CHEMBL5291138)
Affinity DataIC50: 49nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate incubated for 30 mins by Amplex Red reagent based fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50594961(CHEMBL5201233)
Affinity DataIC50: 140nMAssay Description:Inhibition of LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50986(SMR000232286 | MLS000563434 | cid_160876)
Affinity DataIC50: 140nMAssay Description:Inhibition of LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) using H3K4me2 peptide as substrate incubated for 30 mins by Amplex Red re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50587726(CHEMBL3401107)
Affinity DataIC50: 183nMAssay Description:Inhibition of LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) using H3K4me2 peptide as substrate incubated for 30 mins by Amplex Red re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataIC50: 600nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50441978(CHEMBL2334501)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50214969(Mangostin | alpha-mangostin | 1,3,6-Trihydroxy-7-m...)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of LSD1 (unknown origin) by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407799(CHEMBL5282190)
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of LSD1 (unknown origin) by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50242173((2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-4...)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of recombinant LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407801(CHEMBL5284058)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407720(CHEMBL5279958)
Affinity DataIC50: 5.27E+3nMAssay Description:Inhibition of human GST-tagged LSD1 demethylase activity using H3K4 peptide as substrate by MALDI-TOF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407803(CHEMBL5274732)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407805(CHEMBL5274387)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407807(CHEMBL5270254)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407798(CHEMBL3134309)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using methylated histone H3K4 peptide as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407802(CHEMBL5271269)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407808(CHEMBL5283677)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50158878(CHEMBL3785551)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of LSD1 (unknown origin) using methylated histone H3K4 peptide as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of LSD1 (unknown origin) demethylase activity using histone as substrate by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407719(CHEMBL5281939)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human GST-tagged LSD1 demethylase activity using H3K4 peptide as substrate by MALDI-TOF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407797(CHEMBL5290659)
Affinity DataIC50: 1.61E+4nMAssay Description:Inhibition of LSD1 (unknown origin) using methylated histone H3K4 peptide as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50594961(CHEMBL5201233)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) by MAO-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50594961(CHEMBL5201233)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) by MAO-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50445351(NAMOLINE)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of GST-tagged human LSD1 (2 to 852 residues) expressed in baculovirus using H3K4me2 as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407807(CHEMBL5270254)
Affinity DataIC50: 6.39E+4nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407802(CHEMBL5271269)
Affinity DataIC50: 6.57E+4nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407801(CHEMBL5284058)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407805(CHEMBL5274387)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407803(CHEMBL5274732)
Affinity DataIC50: 1.02E+5nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407808(CHEMBL5283677)
Affinity DataIC50: 1.09E+5nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407803(CHEMBL5274732)
Affinity DataIC50: 1.14E+5nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407801(CHEMBL5284058)
Affinity DataIC50: 1.38E+5nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407802(CHEMBL5271269)
Affinity DataIC50: 1.87E+5nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407805(CHEMBL5274387)
Affinity DataIC50: 2.26E+5nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407807(CHEMBL5270254)
Affinity DataIC50: 2.98E+5nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407808(CHEMBL5283677)
Affinity DataIC50: 3.44E+5nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) by Spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407800(CHEMBL5291138)
Affinity DataKi:  16nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate incubated for 30 mins by Amplex Red reagent based fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  40nMAssay Description:Inhibition of human LSD1 expressed in Escherichia coli using pLys4Met peptide as substrate by UV-visible spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  50nMAssay Description:Inhibition of human GST-tagged LSD1/CoREST (305 to 482 residues) expressed in Escherichia coli using pLys4Met peptide as substrate by UV-visible spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50586363(CHEMBL5079374)
Affinity DataKi:  140nMAssay Description:Inhibition of human His-tagged LSD1(171 to 836 residues)/GST-tagged CoREST (308 to 440 residues) using H3K4 peptide as substrate by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407795(CHEMBL5281080)
Affinity DataKi:  157nMAssay Description:Inhibition of human LSD1/CoREST expressed in Escherichia coli using histone H3K4me peptide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407796(CHEMBL1255711)
Affinity DataKi:  193nMAssay Description:Inhibition of human LSD1/CoREST expressed in Escherichia coli using histone H3K4me peptide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407722(CHEMBL5287743)
Affinity DataKi:  210nMAssay Description:Inhibition of human His-tagged LSD1(171 to 836 residues)/GST-tagged CoREST (308 to 440 residues) using H3K4 peptide as substrate by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407723(CHEMBL5274037)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) expressed in Escherichia coli Rosetta 2 strain using H3K4me1 (1 to 21 residues) as substrate by Amplex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50407721(CHEMBL5266466)
Affinity DataKi:  2.84E+4nMAssay Description:Inhibition of human His-tagged LSD1(171 to 836 residues)/GST-tagged CoREST (308 to 440 residues) using H3K4 peptide as substrate by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed