Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50017363
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK2 (835 to 1132 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 300nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 500nMAssay Description:Inhibition of FynT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNeutrophil elastase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50601432(CHEMBL5200257)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pnitroanilide as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNeutrophil elastase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50041292(1-(2-Acetylamino-propionyl)-pyrrolidine-2-carboxyl...)
Affinity DataKi:  210nMAssay Description:Inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNeutrophil elastase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50037115(2-(3-Acetylamino-2-oxo-2H-pyridin-1-yl)-N-(3,3,3-t...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed