Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50013181
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 1.58nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins before CCL2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins before CCL2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50503155(CHEMBL4519152)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50503155(CHEMBL4519152)
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins before CCL2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins before CCL2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563424(CHEMBL4793148)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563424(CHEMBL4793148)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563423(CHEMBL4791522)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563423(CHEMBL4791522)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human CCR2 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human CCR2 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563425(CHEMBL4795646)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563425(CHEMBL4795646)
Affinity DataKi:  63.1nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 79nMAssay Description:Antagonist activity at human CCR2 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 87nMAssay Description:Antagonist activity at human CCR2 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 103nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 3.98E+3nMAssay Description:Antagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 3.98E+3nMAssay Description:Antagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed