Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50018628
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50610495(CHEMBL5286775)
Affinity DataKd:  0.530nMAssay Description:Inhibition of PIK3C3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal GST tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected Sf21 cells by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of His tagged recombinant human FLT3 (564 to 958 residues) expressed in baculovirus expression system incubated for 1.5 hrs in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal 6his tagged recombinant human FGFR2 (456 to 770 residues) expressed in baculovirus infected Sf21 cells by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PDGFRalpha (unknown origin) incubated for 1.5 hrs in the presence of ATP by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50: 3nMAssay Description:Inhibition of FGFR1 (unknown origin) by Z'-LYTE Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of N-terminal 6his tagged recombinant human FGFR3 (447 to 761 residues) expressed in baculovirus infected Sf21 cells by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CSF1-R (unknown origin) by Z'-LYTE Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of His tagged recombinant human FGFR1 (308 to 731 residues) expressed in baculovirus expression system incubated for 1.5 hrs in the presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant VEGFR3 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of recombinant VEGFR1 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50: 7nMAssay Description:Inhibition of VEGFR1 (unknown origin) in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant PDGFRbeta (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST tagged recombinant human FGFR1 V561M mutant (456 to 765 residues) expressed in baculovirus infected Sf21 cells by ELISA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR3 (unknown origin) in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal 6his tagged recombinant human FGFR2 N549H mutant (456 to 770 residues) expressed in baculovirus infected Sf21 cells by ELISA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of PDGFR-beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50: 18nMAssay Description:Inhibition of FGFR1 (unknown origin) in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50: 21nMAssay Description:Inhibition of FGFR2 (unknown origin) by Z'-LYTE Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant PDGFRalpha (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50: 25nMAssay Description:Inhibition of VEGFR2 (unknown origin) in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50324284((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal 6-His tagged recombinant VEGFR2 Kinase domain (unknown origin) expressed in baculovirus expression system incubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant VEGFR1 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50: 31nMAssay Description:Inhibition of FGFR3 (unknown origin) by Z'-LYTE Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant FGFR4 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50: 35nMAssay Description:Inhibition of FGFR4 (unknown origin) by Z'-LYTE Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50324284((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50: 42nMAssay Description:Inhibition of N-terminal 6-His tagged recombinant PDGFRbeta Kinase domain (unknown origin) expressed in baculovirus expression system incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50: 43nMAssay Description:Inhibition of EGFR (unknown origin) by Z'-LYTE Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor substrate 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 59nMAssay Description:Inhibition of FRS2 phosphorylation at Tyr196 residue in human SNU-16 cells incubated for 20 mins by electrochemiluminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50: 83nMAssay Description:Inhibition of FGFR2 (unknown origin) in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50251095(CHEMBL4077930)
Affinity DataIC50: 84nMAssay Description:Inhibition of FGFR4 (unknown origin) using biotin as substrate incubated for 1 hrs in the presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50251095(CHEMBL4077930)
Affinity DataIC50: 86nMAssay Description:Inhibition of EGFR (unknown origin) using biotin as substrate incubated for 1 hrs in the presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor substrate 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 89nMAssay Description:Inhibition of FRS2 phosphorylation at Tyr196 residue in human RT-4 cells incubated for 20 mins by electrochemiluminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor substrate 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 93nMAssay Description:Inhibition of FRS2 phosphorylation at Tyr196 residue in human NCI-H1581 cells incubated for 20 mins by electrochemiluminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50324284((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal 6-His tagged recombinant FGFR1 Kinase domain (unknown origin) expressed in baculovirus expression system incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed