Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 50018225
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PDE8B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407411(CHEMBL5268162)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407412(CHEMBL5269793)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407422(CHEMBL5276601)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human PDE5A1 expressed in baculovirus in Sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50540040(CHEMBL4640793)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PDE1C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50540044(CHEMBL4644729)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PDE1C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407424(CHEMBL5273541)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PDE5A using (Fl)-cAMP and TAMRA-cGMP as substrate incubated for 60 mins by IMAP-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407408(CHEMBL5267226)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PDE2A using [3H]-cAMP as substrate incubated for 30 mins by radiometric based liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407410(CHEMBL5276846)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant PDE2A using [3H]-cAMP as substrate incubated for 30 mins by radiometric based liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM563564(US11419874, Example 5)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant PDE2A using [3H]-cAMP as substrate incubated for 30 mins by radiometric based liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407407(CHEMBL5268661)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant PDE2A using cGMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50540035(CHEMBL4649493)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PDE1C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM566470(US11419874, Example 20)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14768((R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrol...)
Affinity DataIC50: 6nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PDE5A using (Fl)-cAMP and TAMRA-cGMP as substrate incubated for 60 mins by IMAP-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant full length PDE1B in human myocardium using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407400(CHEMBL5285855)
Affinity DataIC50: 11nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407427(CHEMBL5275356)
Affinity DataIC50: 15nMAssay Description:Inhibition of PDE5A1 (unknown origin) using FAM-cGMP as substrate incubated for 60 mins by IMAP-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM317095(US9617269, Compound WYQ-46)
Affinity DataIC50: 16nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50459163(CHEMBL4210889)
Affinity DataIC50: 17nMAssay Description:Inhibition of human PDE5A1 catalytic domain expressed in Escherichia coli using 3[H]-cGMP incubated for 15 mins by liquid scintillation counter analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407416(CHEMBL5278195)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant PDE4B1 using FAM-cAMP as substrate incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Mouse)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50543968(CHEMBL4636079)
Affinity DataIC50: 22nMAssay Description:Inhibition of mouse PDE9A expressed in baculovirus infected Sf9 insect cells using 3[H]-cGMP as substrate incubated for 60 mins by scintillation prox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50258933(CHEMBL4068452)
Affinity DataIC50: 24nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407431(CHEMBL5267538)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant PDE9A (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50: 26nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50029954((7R,7aS)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-hex...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant PDE4B1 using FAM-cAMP as substrate incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407426(CHEMBL5271210)
Affinity DataIC50: 32nMAssay Description:Inhibition of PDE5A1 (unknown origin) using FAM-cGMP as substrate incubated for 60 mins by IMAP-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50513227(CHEMBL4547969)
Affinity DataIC50: 34nMAssay Description:Inhibition of PDE9 (unknown origin) using 3[H]-cGMP as substrate incubated for 15 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 36nMAssay Description:Inhibition of PDE5A1 (unknown origin) using FAM-cGMP as substrate incubated for 60 mins by IMAP-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407410(CHEMBL5276846)
Affinity DataIC50: 53nMAssay Description:Inhibition of human recombinant PDE10A using [3H]-cAMP as substrate incubated for 30 mins by radiometric based liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407430(CHEMBL5277578)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant PDE9A (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50540047(CHEMBL4644938)
Affinity DataIC50: 56nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50591632(CHEMBL5184593)
Affinity DataIC50: 114nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407406(CHEMBL3601546)
Affinity DataIC50: 130nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Rat)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 153nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate incubated for 20 mins by DTNB-reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50467504(CHEMBL4288354)
Affinity DataIC50: 160nMAssay Description:Inhibition of human PDE5A using FL-cGMP as substrate incubated for 1.5 hrs by IMAP-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50467502(CHEMBL4288752)
Affinity DataIC50: 190nMAssay Description:Inhibition of human PDE5A using FL-cGMP as substrate incubated for 1.5 hrs by IMAP-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407401(CHEMBL5269084)
Affinity DataIC50: 219nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407428(CHEMBL5288859)
Affinity DataIC50: 220nMAssay Description:Inhibition of PDE4A (unknown origin) using cAMP as substrate incubated for 30 mins by Ba(OH)2 precipitation assay based scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407428(CHEMBL5288859)
Affinity DataIC50: 280nMAssay Description:Inhibition of PDE8A (unknown origin) using cAMP as substrate incubated for 30 mins by Ba(OH)2 precipitation assay based scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407415(CHEMBL5287106)
Affinity DataIC50: 290nMAssay Description:Displacement of [3H]-cAMP from full-length recombinant human PDE4B1 by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407415(CHEMBL5287106)
Affinity DataIC50: 310nMAssay Description:Displacement of [3H]-cAMP from full-length recombinant human PDE4D7 by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50258897(CHEMBL4087340)
Affinity DataIC50: 480nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50272570(CHEMBL4129844)
Affinity DataIC50: 596nMAssay Description:Inhibition of recombinant full length PDE1B in human myocardium using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM563564(US11419874, Example 5)
Affinity DataIC50: 670nMAssay Description:Inhibition of human recombinant PDE10A using [3H]-cAMP as substrate incubated for 30 mins by radiometric based liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50591632(CHEMBL5184593)
Affinity DataIC50: 673nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50027175(CHEMBL364291)
Affinity DataIC50: 800nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Rural Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50407414(CHEMBL27220)
Affinity DataIC50: 900nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
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