Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50013436
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565841(CHEMBL4795253)
Affinity DataKd:  8.80nMAssay Description:Binding affinity to biotinylated human recombinant NLRP3 PYD domain by biolayer interferometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565841(CHEMBL4795253)
Affinity DataKd:  1.72E+4nMAssay Description:Binding affinity to biotinylated human recombinant NLRP3 NACHT domain by biolayer interferometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 in mouse BMDMsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of NLRP3 in human monocyte-derived macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565841(CHEMBL4795253)
Affinity DataIC50: 7.81E+3nMAssay Description:Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release pre-treated for 24 hrs followed by stimulation with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565843(CHEMBL4786963)
Affinity DataIC50: 9.86E+3nMAssay Description:Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release pre-treated for 24 hrs followed by stimulation with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565845(CHEMBL4781934)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release pre-treated for 24 hrs followed by stimulation with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565840(CHEMBL4796009)
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release pre-treated for 24 hrs followed by stimulation with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565844(CHEMBL4798266)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release pre-treated for 24 hrs followed by stimulation with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565842(CHEMBL4792984)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release pre-treated for 24 hrs followed by stimulation with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed