Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50015579
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50587662(CHEMBL1915474)
Affinity DataIC50: 0.978nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) incubated for 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 40 mins by intrinsic ATPase activity luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50587662(CHEMBL1915474)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of RAF1 (unknown origin) incubated for 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50587664(CHEMBL5181518)
Affinity DataIC50: 21nMAssay Description:Inhibition of human BRAF V600E mutant using MEK1 as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human BRAF V600E mutant using MEK1 as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50587663(CHEMBL5207384)
Affinity DataIC50: 35nMAssay Description:Inhibition of human BRAF V600E mutant using MEK1 as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50562020(CHEMBL4798627)
Affinity DataIC50: 55nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 40 mins by intrinsic ATPase activity luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50587665(CHEMBL5173408)
Affinity DataIC50: 88nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 40 mins by intrinsic ATPase activity luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed