Compile Data Set for Download or QSAR
Report error Found 59 Enz. Inhib. hit(s) with all data for entry = 50012677
LigandChemical structure of BindingDB Monomer ID 50559322BDBM50559322(CHEMBL4787382)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50168472BDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50168472BDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559321BDBM50559321(CHEMBL4754291)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559323BDBM50559323(CHEMBL4794328)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559327BDBM50559327(CHEMBL4787659)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559341BDBM50559341(CHEMBL4783353)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559325BDBM50559325(CHEMBL4756563)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559330BDBM50559330(CHEMBL4778687)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559338BDBM50559338(CHEMBL4752055)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559324BDBM50559324(CHEMBL4782337)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559339BDBM50559339(CHEMBL4750109)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559319BDBM50559319(CHEMBL4791717)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559318BDBM50559318(CHEMBL4751779)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559340BDBM50559340(CHEMBL4742973)
Affinity DataIC50: 7nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559316BDBM50559316(CHEMBL4750646)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559333BDBM50559333(CHEMBL4755417)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559325BDBM50559325(CHEMBL4756563)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559326BDBM50559326(CHEMBL4749877)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559315BDBM50559315(CHEMBL4800682)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kalpha in human MDA-MB-453 cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559317BDBM50559317(CHEMBL4749521)
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50512869BDBM50512869(CHEMBL4463183)
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559331BDBM50559331(CHEMBL4748330)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559329BDBM50559329(CHEMBL4795389)
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559335BDBM50559335(CHEMBL4792005)
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559325BDBM50559325(CHEMBL4756563)
Affinity DataIC50: 18nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559334BDBM50559334(CHEMBL4749578)
Affinity DataIC50: 19nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50168472BDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 21nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50059637BDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)
Affinity DataIC50: 22nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559336BDBM50559336(CHEMBL4748043)
Affinity DataIC50: 26nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559315BDBM50559315(CHEMBL4800682)
Affinity DataIC50: 29nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559327BDBM50559327(CHEMBL4787659)
Affinity DataIC50: 30nMAssay Description:Inhibition of PI3Kgamma in mouse RAW 264.7 cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559337BDBM50559337(CHEMBL4742693)
Affinity DataIC50: 32nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50168472BDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 39nMAssay Description:Inhibition of PI3Kgamma in mouse RAW 264.7 cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50059637BDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)
Affinity DataIC50: 48nMAssay Description:Inhibition of PI3Kbeta in human 786-O cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559328BDBM50559328(CHEMBL4784743)
Affinity DataIC50: 54nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559316BDBM50559316(CHEMBL4750646)
Affinity DataIC50: 60nMAssay Description:Inhibition of PI3Kalpha in human MDA-MB-453 cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559323BDBM50559323(CHEMBL4794328)
Affinity DataIC50: 75nMAssay Description:Inhibition of PI3Kgamma in mouse RAW 264.7 cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50512869BDBM50512869(CHEMBL4463183)
Affinity DataIC50: 78nMAssay Description:Inhibition of PI3Kbeta in human 786-O cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50512869BDBM50512869(CHEMBL4463183)
Affinity DataIC50: 90nMAssay Description:Inhibition of PI3Kgamma in mouse RAW 264.7 cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559332BDBM50559332(CHEMBL4797361)
Affinity DataIC50: 114nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559327BDBM50559327(CHEMBL4787659)
Affinity DataIC50: 134nMAssay Description:Inhibition of PI3Kbeta in human 786-O cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559325BDBM50559325(CHEMBL4756563)
Affinity DataIC50: 177nMAssay Description:Inhibition of PI3Kgamma in mouse RAW 264.7 cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559326BDBM50559326(CHEMBL4749877)
Affinity DataIC50: 191nMAssay Description:Inhibition of PI3Kbeta in human 786-O cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559325BDBM50559325(CHEMBL4756563)
Affinity DataIC50: 208nMAssay Description:Inhibition of PI3Kbeta in human 786-O cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559323BDBM50559323(CHEMBL4794328)
Affinity DataIC50: 241nMAssay Description:Inhibition of PI3Kbeta in human 786-O cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559325BDBM50559325(CHEMBL4756563)
Affinity DataIC50: 242nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559323BDBM50559323(CHEMBL4794328)
Affinity DataIC50: 371nMAssay Description:Inhibition of PI3Kalpha in human MDA-MB-453 cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559325BDBM50559325(CHEMBL4756563)
Affinity DataIC50: 377nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559320BDBM50559320(CHEMBL4784696)
Affinity DataIC50: 384nMAssay Description:Inhibition of PI3Kalpha in human MDA-MB-453 cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
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