Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50012961
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561818(CHEMBL4783377)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to N-terminal FLAG-tagged human PRMT5 (1 to 637 residues)/N-terminal thrombin His-tagged MEP50 (2 to 342 residues) expressed in bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561817(CHEMBL4595238)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561818(CHEMBL4783377)
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561807(CHEMBL4750556)
Affinity DataIC50: 52nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561817(CHEMBL4595238)
Affinity DataIC50: 58nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561816(CHEMBL4758857)
Affinity DataIC50: 83nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561818(CHEMBL4783377)
Affinity DataIC50: 200nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561815(CHEMBL4785053)
Affinity DataIC50: 340nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561809(CHEMBL4754732)
Affinity DataIC50: 370nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561811(CHEMBL4764879)
Affinity DataIC50: 530nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561805(CHEMBL4781036)
Affinity DataIC50: 740nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561807(CHEMBL4750556)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561816(CHEMBL4758857)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561806(CHEMBL4764185)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561806(CHEMBL4764185)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561808(CHEMBL4786890)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561810(CHEMBL4778043)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561820(CHEMBL4784017)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561819(CHEMBL4793527)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561814(CHEMBL4740333)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561804(CHEMBL4756374)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561813(CHEMBL4781968)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561819(CHEMBL4793527)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561820(CHEMBL4784017)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561812(CHEMBL4781317)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561814(CHEMBL4740333)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed