Compile Data Set for Download or QSAR
Report error Found 77 Enz. Inhib. hit(s) with all data for entry = 50011593
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549018(CHEMBL4799863)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of human ERG by Qpatch methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188 | US20250109139, Compound Ca...)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188 | US20250109139, Compound Ca...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549018(CHEMBL4799863)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549038(CHEMBL504548 | CHEBI:71257)
Affinity DataKi:  1nMAssay Description:Binding affinity to H1 histamine receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549021(CHEMBL4797996)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549019(CHEMBL4753808)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549038(CHEMBL504548 | CHEBI:71257)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549032(CHEMBL4759975)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549033(CHEMBL4741702)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188 | US20250109139, Compound Ca...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549032(CHEMBL4759975)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549033(CHEMBL4741702)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549025(CHEMBL4784751)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549019(CHEMBL4753808)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549021(CHEMBL4797996)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549037(CHEMBL4752414)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549018(CHEMBL4799863)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549021(CHEMBL4797996)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549026(CHEMBL4762024)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549023(CHEMBL4788140)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50095890(2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-...)
Affinity DataKi:  7nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  7nMAssay Description:Binding affinity to H1 histamine receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549022(CHEMBL4750939)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549036(CHEMBL4761274)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549029(CHEMBL4756826)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549026(CHEMBL4762024)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549027(CHEMBL4741673)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549029(CHEMBL4756826)
Affinity DataKi:  9.80nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50095890(2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-...)
Affinity DataKi:  11nMAssay Description:Binding affinity to H1 histamine receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  11nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549019(CHEMBL4753808)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549026(CHEMBL4762024)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549034(CHEMBL4743651)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549018(CHEMBL4799863)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549019(CHEMBL4753808)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549031(CHEMBL4755563)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549035(CHEMBL4762918)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188 | US20250109139, Compound Ca...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  19nMAssay Description:Binding affinity to adrenergic alpha1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  20nMAssay Description:Binding affinity to H1 histamine receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549028(CHEMBL4745809)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549023(CHEMBL4788140)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188 | US20250109139, Compound Ca...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549022(CHEMBL4750939)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549027(CHEMBL4741673)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549025(CHEMBL4784751)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549018(CHEMBL4799863)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50549025(CHEMBL4784751)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
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