Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50011581
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321867((E)-1-(4-(5-Methyl-1,2,4-oxadiazol-3-yl)piperidin-...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548813(CHEMBL4786202)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322044(US10183025, Example 140.1 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321898((E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)meth...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321948((E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548807(CHEMBL4794343)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321865((E)-1-(4-(3-Methyl-1,2,4-oxadiazol-5-yl)piperidin-...)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548815(CHEMBL4790845)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321948((E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ATX in human serum assessed as reduction in LPA (18:1) level by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548804(CHEMBL4795515)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548814(CHEMBL4781284)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321906((E)-1-(4-(3-Methyl-1H-1,2,4-triazol-1-yl)piperidin...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548812(CHEMBL4790906)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548811(CHEMBL4748162)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548809(CHEMBL4783839)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548806(CHEMBL4747057)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322046(US10183025, Example 140.3 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322052(US10183025, Example 140.9 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548805(CHEMBL4779450)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322031((E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)meth...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322045(US10183025, Example 140.2 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548810(CHEMBL4740639)
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548803(CHEMBL4753859)
Affinity DataIC50: 790nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548808(CHEMBL4781781)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322044(US10183025, Example 140.1 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321898((E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)meth...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322045(US10183025, Example 140.2 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321865((E)-1-(4-(3-Methyl-1,2,4-oxadiazol-5-yl)piperidin-...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322052(US10183025, Example 140.9 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548806(CHEMBL4747057)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548804(CHEMBL4795515)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322046(US10183025, Example 140.3 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321948((E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548803(CHEMBL4753859)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321906((E)-1-(4-(3-Methyl-1H-1,2,4-triazol-1-yl)piperidin...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322031((E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)meth...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50548805(CHEMBL4779450)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321867((E)-1-(4-(5-Methyl-1,2,4-oxadiazol-3-yl)piperidin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed