Compile Data Set for Download or QSAR
Report error Found 172 Enz. Inhib. hit(s) with all data for entry = 50017951
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606478(CHEMBL5220511)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606473(CHEMBL5220945)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Cdk4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of EGFR T790M (unknown origin) incubated for 40 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606482(CHEMBL5220907)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE5 (unknown origin) incubated for 1.5 hrs by IMAP fluorescence polarization phosphodiesterase evaluation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Cdk4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50142796(CHEMBL3759186)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of EGFR wildtype (unknown origin) incubated for 40 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50591644(CHEMBL5206589)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of HDAC-6 (unknown origin) expressed in Escherichia coli BL21 (DE3) in HeLa nuclear extract using Boc-Lys(TFA)-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307768(7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606484(CHEMBL5220848)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307775(7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquina...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307776(7-(4-(3-Ethynyl-4-fluorophenylamino)-7-methoxyquin...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307768(7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307781(7-(4-(3-Chloro-4-fluorophenylamino)quinazolin-6-yl...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50540803(CHEMBL4633299)
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606473(CHEMBL5220945)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606475(CHEMBL3218002)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307775(7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquina...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50527615(CHEMBL4455923)
Affinity DataIC50: 7nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50527615(CHEMBL4455923)
Affinity DataIC50: 9nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50540804(CHEMBL4639495)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Cdk6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) in HeLa nuclear extract using KI177 as substrate preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50527615(CHEMBL4455923)
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human HDAC2 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606481(CHEMBL5219000)
Affinity DataIC50: 14nMAssay Description:Inhibition of HDAC (unknown origin) by H4 Hybrid Multi-Mode Microplate ReadeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307768(7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50591644(CHEMBL5206589)
Affinity DataIC50: 17nMAssay Description:Inhibition of HDAC-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) in HeLa nuclear extract using KI177 as substrate preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307775(7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquina...)
Affinity DataIC50: 19nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50540098(CHEMBL4649154)
Affinity DataIC50: 21nMAssay Description:Inhibition of human HDAC6 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606485(CHEMBL5218513)
Affinity DataIC50: 23nMAssay Description:Inhibition of HDAC1 in human HeLa cell nuclear extract using Bos-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606473(CHEMBL5220945)
Affinity DataIC50: 26nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50540098(CHEMBL4649154)
Affinity DataIC50: 29nMAssay Description:Inhibition of human HDAC1 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50307776(7-(4-(3-Ethynyl-4-fluorophenylamino)-7-methoxyquin...)
Affinity DataIC50: 29nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 30nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50540095(CHEMBL4643070)
Affinity DataIC50: 30nMAssay Description:Inhibition of human HDAC6 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: 31nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 33nMAssay Description:Inhibition of HDAC-6 (unknown origin) expressed in Escherichia coli BL21 (DE3) in HeLa nuclear extract using Boc-Lys(TFA)-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human HDAC6 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50540099(CHEMBL4644409)
Affinity DataIC50: 38nMAssay Description:Inhibition of human HDAC1 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50606474(CHEMBL3218001)
Affinity DataIC50: 41nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50540098(CHEMBL4649154)
Affinity DataIC50: 41nMAssay Description:Inhibition of human HDAC2 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50540099(CHEMBL4644409)
Affinity DataIC50: 41nMAssay Description:Inhibition of human HDAC6 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
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