Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50018379
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human recombinant mTOR assessed as decrease in phosphorylation of S6K level at Thr389 incubated for 2 hrs in presence of ATP and His6-S...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full length mTOR in human HeLa cells using 4EBP1 as substrate by immunoprecipitation based ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of C-terminal His-tagged full-length PI3K p110alpha (unknown origin) expressed in baculovirus incubated for 60 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal His-tagged full-length PI3K p110delta (unknown origin) expressed in baculovirus incubated for 120 mins by Kinase-Glo lumines...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human recombinant PI3Kalpha in presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of C-terminal His-tagged full-length PI3K p110gamma (unknown origin) expressed in baculovirus incubated for 60 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using 4EBP1 as substrate in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of ATR in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblottin...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of mTORC1 in human HEK293 cells assessed as decrease in phosphorylated S6K level incubated for 30 mins by immunoblot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of ATM in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblottin...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using 4EBP1 as substrate in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of mTORC2 in human HEK293 cells assessed as decrease in phosphorylated Akt level incubated for 30 mins by immunoblot assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of mTOR (unknown origin) by K-LISA assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using 4EBP1 as substrate in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of C-terminal His-tagged full-length PI3K p110beta (unknown origin) expressed in baculovirus incubated for 60 mins by Kinase-Glo luminesce...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of human recombinant PI3Kbeta in presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using 4EBP1 as substrate in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 165nMAssay Description:Inhibition of mTOR (unknown origin) by Lanthascreen kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of mTOR in rat brain by [3H]-thymidine incorporation based immunoblot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of mTORC2 in human LN-229 cells assessed as decrease in phosphorylation of AKT at Ser473 level incubated for 24 hrs by immunoblot assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human PI3Kalpha assessed as inhibition constantMore data for this Ligand-Target Pair
3D Structure (crystal)TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human PI3Kbeta assessed as inhibition constantMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human PI3Kgamma assessed as inhibition constantMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human PI3Kdelta assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of human mTOR assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Inhibition of mTOR (unknown origin) assessed as inhibition constant using GFP-4EBP1 as substrate by Lanthascreen based time resolved fluorescence bas...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataKi: 380nMAssay Description:Inhibition of PIK3alpha (unknown origin) expressed in baculovirus assessed as inhibition constant using PIP2 as substrate in presence of [gamma-32P]A...More data for this Ligand-Target Pair
