Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50013806
TargetHistone deacetylase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569832(CHEMBL4863294)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569833(CHEMBL4866341)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HDAC1 (unknown origin) by color-de-lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569832(CHEMBL4863294)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50510962(CHEMBL4454646)
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal His-tagged human HDAC3 (1 to 428 residues)/N-terminal GST tagged human NCOR2 (395 to 489) expressed in baculovirus expressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC class1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569832(CHEMBL4863294)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569833(CHEMBL4866341)
Affinity DataIC50: 17nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 19nMAssay Description:Inhibition of human PI3K alpha by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of human HDAC1 expressed in baculovirus expression system by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 39nMAssay Description:Inhibition of human PI3K delta by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataIC50: 54nMAssay Description:Inhibition of human PI3K beta by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569834(CHEMBL4870955)
Affinity DataIC50: 85nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569837(CHEMBL4878570)
Affinity DataIC50: 930nMAssay Description:Inhibition of DNMT3A (unknown origin) using biotinylated DNA oligonucleotides as substrate in presence of [3H-SAM] preincubated for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569837(CHEMBL4878570)
Affinity DataIC50: 2.02E+3nMAssay Description:Inhibition of DNMT1 (unknown origin) using poly(dI-dC)-poly(dI-dC as substrate in presence of [3H-SAM] preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569837(CHEMBL4878570)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-peptide as substrate in preincubated for 15 mins followed by substrate addition and measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569835(CHEMBL4850917)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of HDAC in human K562 cells using Boc-K(Ac)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569834(CHEMBL4870955)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569835(CHEMBL4850917)
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as effect on H3K9Me2 levels incubated for 48 hrs by immunofluorescence in-cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed