Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50012291
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556210(CHEMBL4759664)
Affinity DataIC50: 234nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556217(CHEMBL4784819)
Affinity DataIC50: 248nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556215(CHEMBL4746451)
Affinity DataIC50: 254nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556218(CHEMBL4753468)
Affinity DataIC50: 261nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556213(CHEMBL4740722)
Affinity DataIC50: 266nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556219(CHEMBL4798501)
Affinity DataIC50: 269nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50266426(CHEMBL4076808)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556211(CHEMBL4786788)
Affinity DataIC50: 359nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556216(CHEMBL4754272)
Affinity DataIC50: 391nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556207(CHEMBL4790566)
Affinity DataIC50: 396nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556208(CHEMBL4758134)
Affinity DataIC50: 452nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556209(CHEMBL4788185)
Affinity DataIC50: 640nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556214(CHEMBL4795313)
Affinity DataIC50: 687nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556220(CHEMBL4740413)
Affinity DataIC50: 717nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556212(CHEMBL4744487)
Affinity DataIC50: 909nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataKi:  3.60nMAssay Description:Competitive inhibition of recombinant human C-terminal His-tagged SphK1 expressed in baculovirus infected Sf21 cells using varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of recombinant SphK2 (unknown origin) using sphingosine as substrate by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556206(CHEMBL4748833)
Affinity DataKi:  6.90E+3nMAssay Description:Inhibition of recombinant human Flag-tagged SphK2 transfected in HEK293 cells using d-erythro-sphingosine as substrate by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length SphK2 expressed in baculovirus infected Sf9 cells using C17-sphingosine as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50393641(CHEMBL2158686)
Affinity DataKi:  1.65E+4nMAssay Description:Inhibition of recombinant SphK2 (unknown origin) using sphingosine as substrate incubated for 15 to 20 mins by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50556206(CHEMBL4748833)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of recombinant human Flag-tagged SphK1 transfected in HEK293 cells using d-erythro-sphingosine as substrate by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed