Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50013675
LigandPNGBDBM160445(US9040714, 167 | US9693992, 167)
Affinity DataEC50: <1.00E+4nMAssay Description:Inhibition of IRE1 in human SUM159 cells incubated for 10 days by crystal violet staining based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM111376(US8614253, 33-3 | US8614253, 32-12 | US9241942, 33...)
Affinity DataIC50: 5nMAssay Description:Inhibition of IRE1 in human RPMI 8226 cells assessed as reduction in XBP1 splicing incubated for 3 hrs by RT-PCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 10nMAssay Description:Inhibition of FGFR4 (unknown origin) expressed in HEK293 cells assessed as reduction in autophosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM110974(US8614253, 3-5 | US9241942, 3-5 | US9963434, Compo...)
Affinity DataIC50: 80nMAssay Description:Inhibition of IRE1 (unknown origin) assessed as reduction in XBP1 splicingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM160445(US9040714, 167 | US9693992, 167)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse IRE1 assessed as reduction in XBP1 splicing using 5'-Alexa Fluor 647-CAUGUCCGCAGCGCAUG-BHQ1-3' as substrate preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed