Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50011884
TargetToll-like receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552134(CHEMBL4759149 | US11472815, Compound 22)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at TLR2 in HEK-Blue hTLR2 cells assessed as NF-kappaB activation preincubated for 24 hrs followed by replacement of medium containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50511984(CHEMBL4581678)
Affinity DataEC50:  550nMAssay Description:Agonist activity at TLR2 in HEK-Blue hTLR2 cells assessed as NF-kappaB activation preincubated for 24 hrs followed by replacement of medium containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552140(CHEMBL4780449)
Affinity DataEC50:  0.470nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552141(CHEMBL4756806)
Affinity DataEC50:  0.280nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552142(CHEMBL4791879)
Affinity DataEC50:  0.380nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552143(CHEMBL4759425)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552139(CHEMBL4790706)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TLR8 in HEK-Blue hTLR8 assessed as reduction in SEAP production incubated for 20 to 24 hrs by Quanti-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552135(CHEMBL4303210)
Affinity DataIC50: 54nMAssay Description:Inhibition of Rho-Pam3 binding to TLR1 (unknown origin)/human TLR2 expressed in HEK293 cells incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 2(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552138(CHEMBL3935646)
Affinity DataIC50: 580nMAssay Description:Inhibition of Pam3CSK4-induced TLR1/TLR2 activation in mouse RAW 264.7 cells assessed as reduction in NO production incubated for 24 hrs by 2,3-diami...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 5(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552136(CHEMBL4795753)
Affinity DataIC50: 850nMAssay Description:Inhibition of Flagellin-BS binding to human TLR5 expressed in HEK293 cells harboring SEAP reporter gene preincubated for 24 hrs followed by compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552137(CHEMBL465158)
Affinity DataIC50: 1.40E+3nMAssay Description:Modulation of TLR4 in human THP1 cells assessed as reduction in LPS-induced TLR4 expression pretreated for 2 hrs followed by LPS challenge and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50552138(CHEMBL3935646)
Affinity DataKi:  410nMAssay Description:Inhibition of rhodamine-labeled Pam3CSK4 binding to TLR1 (unknown origin)/TLR2 (unknown origin) expressed in baculovirus infected sf9 cells incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed