Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with all data for entry = 50012654
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cells using L-tyrosine and DOPA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559077(CHEMBL4473314)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tyrosinase in human neonatal foreskin epidermal melanocyte cells using L-tyrosine and L-DOPA as substrate preincubated for 2 days follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559078(SUBAMOLIDE A)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tyrosinase in human neonatal foreskin epidermal melanocyte cells using L-tyrosine and L-DOPA as substrate preincubated for 2 days follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559093(CHEMBL4763438)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559091(CHEMBL4792744)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cells using L-tyrosine and DOPA as substrate by absorbance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM4374(p-Coumaric Acid | p-hydroxycinnamic acid (M4) | CH...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM4374(p-Coumaric Acid | p-hydroxycinnamic acid (M4) | CH...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of tyrosinase in neonatal human epidermal melanocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559096(CHEMBL4745622)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human tyrosinase expressed in human SKMEL188 cell lysate using L- DOPA as substrate incubated for 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559090(CHEMBL4795966)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559086(CHEMBL4793063)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human HMV-II cell derived tyrosinase using L-DOPA as substrate by light absorbance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50120828(CHEMBL590969)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM49898(SMR000277244 | 4-[2-(pyrimidin-2-ylamino)-1,3-thia...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559089(CHEMBL4782537)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559092(CHEMBL4757374)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of tyrosinase in human melanocyte cells using L-DOPA as substrate by absorbance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human HMV-II cell derived tyrosinase using DOPA as substrate incubated for 5 mins by light absorbance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50192746(CHEMBL3343986)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human HMV-II cell derived tyrosinase using DOPA as substrate incubated for 5 mins by light absorbance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50410495(CHEMBL16217)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of tyrosinase in human melanocytes using L-[3,5-3H]-tyrosine as substrate incubated for 1 to 3 days by liquid scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559097(CHEMBL4757912)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559082(CHEMBL4749970)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cells using L-tyrosine as substrate and DOPA as cofactor by indirect spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559085(CHEMBL2413822)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human HMV-II cell derived tyrosinase using DOPA as substrate incubated for 5 mins by light absorbance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559084(CHEMBL4750112)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of tyrosinase in human HBL cell extract using L-DOPA as substrate measured every 10 mins for 1 hr by MBTH based spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50428389(Methyl 3-(4-Hydroxyphenyl)Acrylate | Methyl P-Hydr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of tyrosinase in neonatal human epidermal melanocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559081(CHEMBL492818)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of tyrosinase in human neonatal foreskin epidermal melanocyte cells using L-DOPA as substrate preincubated for 24 hrs followed by cell lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559098(CHEMBL4759198)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559079(N-Trans-Feruloyldopamine | Trans-N-Feruloyldopamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of tyrosinase in neonatal human epidermal melanocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50293593(4-(2-aminothiazol-4-yl)benzene-1,3-diol | CHEMBL54...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cells using L-tyrosine as substrate and DOPA as cofactor by indirect spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559083(CHEMBL4750803)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of tyrosinase in human HBL cell extract using L-DOPA as substrate measured every 10 mins for 1 hr by MBTH based spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559080(CHEMBL4751258)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of tyrosinase in human neonatal foreskin epidermal melanocyte cells using L-DOPA as substrate preincubated for 24 hrs followed by cell lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50292636(4-hexyl resorcinol | CHEMBL443605 | ACRISORCIN)
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM240731(US9422261, 4-(1- phenylethyl) benzene-1,3- diol)
Affinity DataIC50: 1.31E+5nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50031467(Kojic Acid | CHEMBL287556 | 5-HYDROXY-2-(HYDROXYME...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM26189(CHEMBL24147 | benzene-1,3-diol | 1,3-dihydroxybenz...)
Affinity DataIC50: 3.00E+6nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM26190(CHEMBL537 | benzene-1,4-diol | Hydroquinone, HQ | ...)
Affinity DataIC50: 4.40E+6nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50219502(4-hydroxyphenyl beta-D-glucopyranoside | hydroquin...)
Affinity DataIC50: 6.50E+6nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataKi:  250nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50240041(1-phenyl-2-thiourea | N-Phenyl-thiourea | N-Phenyl...)
Affinity DataKi:  1.70E+3nMAssay Description:Uncompetitive inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50206007(3-hydroxy-2H-chromen-2-one | 3-Hydroxy-chromen-2-o...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of human tyrosinase expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataKi:  9.10E+3nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50198715(CHEMBL245416 | L-mimosine | (2S)-2-amino-3-(3-hydr...)
Affinity DataKi:  1.03E+4nMAssay Description:Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal plo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50330108(2-(ethylthiomethyl)-5-hydroxy-4H-pyran-4-one | CHE...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM240731(US9422261, 4-(1- phenylethyl) benzene-1,3- diol)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50330109(5-hydroxy-2-(propylthiomethyl)-4H-pyran-4-one | CH...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50292636(4-hexyl resorcinol | CHEMBL443605 | ACRISORCIN)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50559094(CHEMBL4751526)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
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