Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50011224
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545831BDBM50545831(CHEMBL4632652)
Affinity DataIC50: 15nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364031BDBM50364031(CHEMBL1950434)
Affinity DataIC50: 29nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485974BDBM50485974(CHEMBL2180376)
Affinity DataIC50: 33nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364034BDBM50364034(CHEMBL1950535)
Affinity DataIC50: 37nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425037BDBM50425037(CHEMBL2312555)
Affinity DataIC50: 39nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545820BDBM50545820(CHEMBL4641625)
Affinity DataIC50: 48nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545821BDBM50545821(CHEMBL4643105)
Affinity DataIC50: 52nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545824BDBM50545824(CHEMBL4634921)
Affinity DataIC50: 55nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364033BDBM50364033(CHEMBL1224151)
Affinity DataIC50: 64nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545825BDBM50545825(CHEMBL4648298)
Affinity DataIC50: 69nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545826BDBM50545826(CHEMBL4634696)
Affinity DataIC50: 107nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545823BDBM50545823(CHEMBL4637679)
Affinity DataIC50: 113nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50483255BDBM50483255(CHEMBL1643425)
Affinity DataIC50: 116nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545827BDBM50545827(CHEMBL4642697)
Affinity DataIC50: 143nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545830BDBM50545830(CHEMBL4636430)
Affinity DataIC50: 400nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545832BDBM50545832(CHEMBL4639757)
Affinity DataIC50: 462nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545828BDBM50545828(CHEMBL4643160)
Affinity DataIC50: 512nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545829BDBM50545829(CHEMBL4639056)
Affinity DataIC50: 1.55E+3nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545824BDBM50545824(CHEMBL4634921)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545821BDBM50545821(CHEMBL4643105)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545827BDBM50545827(CHEMBL4642697)
Affinity DataIC50: 2.61E+3nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545826BDBM50545826(CHEMBL4634696)
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545827BDBM50545827(CHEMBL4642697)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545827BDBM50545827(CHEMBL4642697)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545822BDBM50545822(CHEMBL4644009)
Affinity DataIC50: 9.29E+3nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545824BDBM50545824(CHEMBL4634921)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545827BDBM50545827(CHEMBL4642697)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545821BDBM50545821(CHEMBL4643105)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545821BDBM50545821(CHEMBL4643105)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545826BDBM50545826(CHEMBL4634696)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545824BDBM50545824(CHEMBL4634921)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545827BDBM50545827(CHEMBL4642697)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545826BDBM50545826(CHEMBL4634696)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545821BDBM50545821(CHEMBL4643105)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545826BDBM50545826(CHEMBL4634696)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545824BDBM50545824(CHEMBL4634921)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545826BDBM50545826(CHEMBL4634696)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545824BDBM50545824(CHEMBL4634921)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545821BDBM50545821(CHEMBL4643105)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed