Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50011323
TargetTubulin beta-3 chain(Human)
Pennsylvania State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50546440(CHEMBL552462)
Affinity DataIC50: 25nMAssay Description:Binding affinity to beta tubulin in HEK293 cells assessed as disruption of microtubule polymerization by ITDRF-CETSA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pennsylvania State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50546440(CHEMBL552462)
Affinity DataIC50: 60nMAssay Description:Binding affinity to SphK1 in HEK293 cells assessed as direct target engagement incubated for 24 hrs followed by thermal denaturation at 61 degreeC by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Pennsylvania State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50546440(CHEMBL552462)
Affinity DataIC50: 60nMAssay Description:Binding affinity to SphK2 in HEK293 cells assessed as direct target engagement incubated for 24 hrs followed by thermal denaturation at 61 degreeC by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pennsylvania State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50331855(N'-(1-(3,4-dimethoxyphenyl)ethylidene)-3-(4-methox...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant His6x-tagged human SphK1 expressed in HEK293 cells assessed as reduction in S1P formation using D-erythro-sphingosine as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pennsylvania State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50546440(CHEMBL552462)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant His6x-tagged human SphK1 expressed in HEK293 cells assessed as reduction in S1P formation using D-erythro-sphingosine as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed