Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50012776
TargetAcetylcholinesterase(Electric eel)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560224(CHEMBL4751100)
Affinity DataKd:  2.03E+3nMAssay Description:Displacement of propidium iodide from PAS region of electric eel AChE by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560224(CHEMBL4751100)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560225(CHEMBL4785201)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560223(CHEMBL4796461)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560218(CHEMBL4797814)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560217(CHEMBL4787579)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560220(CHEMBL4762419)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560212(CHEMBL4794549)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560209(CHEMBL4749077)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560211(CHEMBL4792460)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560216(CHEMBL4798535)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560210(CHEMBL4757922)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560222(CHEMBL4794645)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560227(CHEMBL4747041)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560214(CHEMBL4789620)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560221(CHEMBL4797177)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560226(CHEMBL4787251)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560215(CHEMBL4747836)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560213(CHEMBL4789172)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560224(CHEMBL4751100)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM8987(6-chlorotacrine.HCl | CHEMBL486698 | 6-chloro-1,2,...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560223(CHEMBL4796461)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560225(CHEMBL4785201)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560214(CHEMBL4789620)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560219(CHEMBL4758624)
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560227(CHEMBL4747041)
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560210(CHEMBL4757922)
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560211(CHEMBL4792460)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560216(CHEMBL4798535)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560215(CHEMBL4747836)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560220(CHEMBL4762419)
Affinity DataIC50: 102nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560212(CHEMBL4794549)
Affinity DataIC50: 111nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560222(CHEMBL4794645)
Affinity DataIC50: 148nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560218(CHEMBL4797814)
Affinity DataIC50: 168nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560217(CHEMBL4787579)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560226(CHEMBL4787251)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560221(CHEMBL4797177)
Affinity DataIC50: 187nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560213(CHEMBL4789172)
Affinity DataIC50: 201nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560209(CHEMBL4749077)
Affinity DataIC50: 275nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM8987(6-chlorotacrine.HCl | CHEMBL486698 | 6-chloro-1,2,...)
Affinity DataIC50: 505nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560219(CHEMBL4758624)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560214(CHEMBL4789620)
Affinity DataIC50: 7.19E+3nMAssay Description:Inhibition human BACE1 expressed in baculovirus expression system using Panvera peptide as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560215(CHEMBL4747836)
Affinity DataIC50: 8.31E+3nMAssay Description:Inhibition human BACE1 expressed in baculovirus expression system using Panvera peptide as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560227(CHEMBL4747041)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition human BACE1 expressed in baculovirus expression system using Panvera peptide as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560213(CHEMBL4789172)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition human BACE1 expressed in baculovirus expression system using Panvera peptide as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560208(CHEMBL4796696)
Affinity DataIC50: 2.32E+4nMAssay Description:Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560208(CHEMBL4796696)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50560224(CHEMBL4751100)
Affinity DataKi:  0.132nMAssay Description:Mixed inhibition of recombinant human AChE expressed in HEK293 cells assessed as dissociation constant for enzyme-inhibitor complex using varying lev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
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