Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50018748
TargetCyclin-dependent kinase 2(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50: 4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50612029(CHEMBL5278077)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM92841(Bisanilinopyrimidine, 9m | US9249124, 57)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50612029(CHEMBL5278077)
Affinity DataIC50: 14nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase C(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Aurora CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM92841(Bisanilinopyrimidine, 9m | US9249124, 57)
Affinity DataIC50: 16nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50: 25nMAssay Description:Inhibition of human MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50: 25nMAssay Description:Inhibition of human Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM92841(Bisanilinopyrimidine, 9m | US9249124, 57)
Affinity DataIC50: 33nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50612029(CHEMBL5278077)
Affinity DataIC50: 51nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50307127((Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 280nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 416nMAssay Description:Inhibition of recombinant full length His-tagged human PDK1 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed