Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50010875
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM21974((2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHE...)
Affinity DataIC50: 6.50E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50103596(CHEBI:9334 | Azulfidine | Azulfidine EN | Azulfidi...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of AICAR transformylase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi:  3.40E+4nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50219500(2-Hydroxy-5-phenylbenzoic acid | 4-hydroxybiphenyl...)
Affinity DataKi:  4.80E+4nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50134036(cid_4044 | mefanamic acid | CHEMBL686 | CI-473 | C...)
Affinity DataKi:  7.20E+4nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50237608(CHEBI:8064 | Phenformin)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM13066({2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |...)
Affinity DataKi:  1.60E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50542901(Diaminopyrimidine)
Affinity DataKi:  1.80E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50542900(CHEMBL3278332 | CHEBI:61114)
Affinity DataKi:  1.80E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataKi:  3.60E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataKi:  5.60E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50241727(L-1-methyl-tryptophan | (S)-2-amino-3-(1-methyl-1H...)
Affinity DataKi:  8.10E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50043799((2R)-2-amino-3-(1H-indol-3-yl)propanoic acid | (R)...)
Affinity DataKi:  8.80E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi:  1.80E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataKi:  7.00E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataKi:  3.40E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50009999(CHEMBL461 | N-benzoylglycine)
Affinity DataKi:  1.70E+7nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM21974((2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHE...)
Affinity DataKi:  2.80E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50229665(N,N-dimethylimidodicarbonimidic diamide | 1,1-Dime...)
Affinity DataKi:  1.80E+7nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed