Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50010546
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540028BDBM50540028(CHEMBL4635769)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540030BDBM50540030(CHEMBL4633392)
Affinity DataIC50: 2nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540025BDBM50540025(CHEMBL4639517)
Affinity DataIC50: 2nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540029BDBM50540029(CHEMBL4648587)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540026BDBM50540026(CHEMBL4645846)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 7nMAssay Description:Inhibition of autotaxin in mouse plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370043BDBM370043((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-4-oxo-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 14nMAssay Description:Inhibition of autotaxin in human plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370050BDBM370050((R)-4-(8-(2-(2-Fluoro-5-(trifluoromethyl)benzamido...)
Affinity DataIC50: 31nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369944BDBM369944((R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 34nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370016BDBM370016((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-p...)
Affinity DataIC50: 38nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370019BDBM370019((R)—N-(1-(1-(3-Chlorophenyl)-3-methyl-2,4-dio...)
Affinity DataIC50: 46nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 55nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540028BDBM50540028(CHEMBL4635769)
Affinity DataIC50: 56nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540025BDBM50540025(CHEMBL4639517)
Affinity DataIC50: 86nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369934BDBM369934(US10233182, Example 190 | (R)-2-Fluoro-N-(3-methyl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369946BDBM369946(US10233182, Example 59)
Affinity DataIC50: 340nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540027BDBM50540027(CHEMBL4638762)
Affinity DataIC50: 350nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369899BDBM369899(US10233182, Example 129 | (R)-3-Methyl-N-(2-(3-met...)
Affinity DataIC50: 623nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369876BDBM369876(US10233182, Example 3 | (R)-2-Fluoro-3-methyl-N-(3...)
Affinity DataIC50: 683nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540031BDBM50540031(CHEMBL4646195)
Affinity DataIC50: 819nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540032BDBM50540032(CHEMBL4636626)
Affinity DataIC50: 905nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369827BDBM369827(US10233182, Example 68 | (R)—N-(1-(1-(1H-Inda...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369824BDBM369824(US10233182, Example 61 | (R)—N-(1-(1-(1H-Inda...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 3(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPAR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 2(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPAR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369829BDBM369829(US10233182, Example 70 | N-(2-(1-(1H-Indazol-5-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPAR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ENPP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369828BDBM369828(US10233182, Example 69 | (S)—N-(1-(1-(1H-Inda...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369852BDBM369852(US10233182, Example 130 | (S)-3-Methyl-N-(2-(3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
X-Chem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human ERG by GLP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 369940BDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed