Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50018493
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50412286(CHEMBL476730)
Affinity DataKd:  3.61E+4nMAssay Description:Binding affinity to recombinant Bcl-2 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by MST analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataEC50:  2.80E+3nMAssay Description:Inhibition of Flu-BakBH3 binding to GST-tagged Bcl-2 (unknown origin) preincubated for 10 mins followed by Flu-BakBH3 addition and measured after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50: 200nMAssay Description:Inhibition of BH3 peptide binding to Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50: 310nMAssay Description:Inhibition of BH3 peptide binding to Bcl-xL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50: 320nMAssay Description:Inhibition of BH3 peptide binding to Bcl-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50: 620nMAssay Description:Inhibition of BH3 peptide binding to Bfl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50505361(CHEMBL4530348)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of Bcl-2 (unknown origin) by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50234313(CHEMBL4102399)
Affinity DataIC50: 4.27E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50200965(Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoeth...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of Flu-BakBH3 binding to recombinant GST-tagged Bcl-2 (unknown origin) incubated for 30 mins by competitive fluorescence polarization assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50558853(CHEMBL4465826)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to recombinant His-tagged human Bcl-xL expressed in Escherichia coli assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50608721(CHEMBL5283370)
Affinity DataKi:  9.5nMAssay Description:Binding affinity to recombinant His-tagged human Bcl-2 expressed in Escherichia coli assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50558853(CHEMBL4465826)
Affinity DataKi:  17nMAssay Description:Binding affinity to recombinant His-tagged human Bcl-2 expressed in Escherichia coli assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50608722(CHEMBL5278443)
Affinity DataKi:  22nMAssay Description:Binding affinity to recombinant His-tagged human Bcl-xL expressed in Escherichia coli assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50608723(CHEMBL5285186)
Affinity DataKi:  25nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50608723(CHEMBL5285186)
Affinity DataKi:  35nMAssay Description:Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  48nMAssay Description:Binding affinity to Bcl-xL (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  245nMAssay Description:Binding affinity to Bcl-w (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM23223(Tash 1 | Gossypol, 4 | 7-[8-formyl-1,6,7-trihydrox...)
Affinity DataKi:  320nMAssay Description:Inhibition of Flu-BakBH3 binding to Bcl-2 (unknown origin) assessed as inhibition constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi: >444nMAssay Description:Binding affinity to Mcl-1 (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50608723(CHEMBL5285186)
Affinity DataKi:  660nMAssay Description:Binding affinity to Bcl-xL (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed